Lysis of cancer cells with release of intracellular contents

DNA

Phosphate

Potassium

Cytokines

Potassium

Phosphate

DNAase breaks down
DNA, releasing purines

No tumor lysis syndrome

Tumor lysis syndrome

End

Acute kidney injury

Hypotension

Acute kidney injury

Inflammation

Guanine

Inosine

Adenosine

Guanosine

Hypoxanthine

Xanthine

Uric acid

Urinary excretion / Accumulation

Rasburicase

Urinary excretion

Accumulation

Allantoin

Allopurinol