Spectrum of HIV Infection

Spectrum of HIV Infection

Group 1	Acute infection or primary HIV infection (a mononucleosis-like syndrome associated with sero-conversion)
Group 2	Asymptomatic infection
Group 3	Symptomatic disease
Group 4	Advanced disease: CD4 count <200×10⁶/L)
	Constitutional disease (e.g. fever, weight loss, diarrhoea)*
	Neurological disease (HIV encephalopathy, opportunistic infection,
	central nervous system lymphoma)
	Secondary infectious diseases: Pneumocystis pneumonia Cytomegalovirus chorioretinitis, colitis, pneumonitis or adrenalitis Candida albicans: oral thrush, oesophagitis Mycobacterium avium-intracellulare: localized or disseminated infection Mycobacterium tuberculosis* infection* Cryptococcus neoformans: meningitis or disseminated infection Toxoplasma gondii: encephalitis or intracerebral mass lesions Herpes simplex virus: severe mucocutaneous lesions, oesophagitis Cryptosporidium spp. diarrhoea Cystoisospora belli diarrhoea
	Secondary neoplasms: Kaposi's sarcoma (cutaneous and visceral) Lymphoma (brain, bone marrow, gut)
	Other conditions (thrombocytopenia, non-specific interstitial pneumonitis)*
AIDS is diagnosed in an HIV-positive patient with group 4 disease, except those marked*