Efficacy in converting VT uncertain

Major role is in suppression of recurrent episodes

Needs to be given via central vein to avoid thrombophlebitis

Loading: 300 mg, diluted in 5% glucose to a volume of 20–50 mL, infused over 20 min via a central vein

Maintenance: 900–1200 mg over 24h

Supplementary doses of 150 mg can be given as necessary every 10 min for recurrent or resistant

VT to a maximum total daily dose of 2.2g

Converts ∼30%

Appropriate when VT is due to myocardial ischaemia or infarction

May cause hypotension and neurological side effects

Loading: 1.5 mg/kg over 2 min

Maintenance: 1–4 mg/min