Causes of Acute Weakness (See Also Table 17.1)
Site | Causes |
---|---|
Brain | Stroke Mass lesion with brainstem compression Central pontine myelinolysis Sedative drugs |
Spinal cord | Spinal cord/cauda equina/root compression (see Chapter 70) Transverse myelitis Anterior spinal artery occlusion Haematomyelia |
Peripheral nerve | Guillain-Barré syndrome Critical illness neuropathy Toxins (heavy metals, biological toxins or drug intoxication) Acute intermittent porphyria Vasculitis (with mononeuritis multiplex) Lymphomatous neuropathy |
Neuromuscular junction | Myasthenia gravis Lambert-Eaton syndrome Biological or industrial toxins |
Muscle | Hypophosphataemia Inflammatory myopathy Critical illness myopathy Acute rhabdomyolysis (see Appendix 25.1) Periodic paralyses |