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Table 71.3

Causes of Acute Weakness (See Also Table 17.1)

SiteCauses
Brain

Stroke

Mass lesion with brainstem compression

Encephalitis

Central pontine myelinolysis

Sedative drugs

Spinal cord

Spinal cord/cauda equina/root compression (see Chapter 70)

Transverse myelitis

Anterior spinal artery occlusion

Haematomyelia

Poliomyelitis

Rabies

Peripheral nerve

Guillain-Barré syndrome

Critical illness neuropathy

Toxins (heavy metals, biological toxins or drug intoxication)

Acute intermittent porphyria

Vasculitis (with mononeuritis multiplex)

Lymphomatous neuropathy

Diphtheria

Neuromuscular junction

Myasthenia gravis

Lambert-Eaton syndrome

Botulism

Biological or industrial toxins

Muscle

Hypokalaemia

Hypophosphataemia

Hypomagnesaemia

Inflammatory myopathy

Critical illness myopathy

Acute rhabdomyolysis (see Appendix 25.1)

Trichinosis

Periodic paralyses