Causes of Acute Weakness (See Also Table 17.1)
| Site | Causes | 
|---|---|
| Brain | Stroke Mass lesion with brainstem compression Central pontine myelinolysis Sedative drugs  | 
| Spinal cord | Spinal cord/cauda equina/root compression (see Chapter 70) Transverse myelitis Anterior spinal artery occlusion Haematomyelia  | 
| Peripheral nerve | Guillain-Barré syndrome Critical illness neuropathy Toxins (heavy metals, biological toxins or drug intoxication) Acute intermittent porphyria Vasculitis (with mononeuritis multiplex) Lymphomatous neuropathy  | 
| Neuromuscular junction | Myasthenia gravis Lambert-Eaton syndrome Biological or industrial toxins  | 
| Muscle | Hypophosphataemia Inflammatory myopathy Critical illness myopathy Acute rhabdomyolysis (see Appendix 25.1) Periodic paralyses  |