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Table 98.3

Initial Antibiotic Therapy for Suspected Native Joint Septic Arthritis

Antibiotic therapy (IV, high dose)
Organisms on Gram stainNot allergic to penicillinAllergic to penicillin
Gram-positive cocci

Flucloxacillin

Vancomycin if MRSA suspected

Clindamycin
Gram-negative cocciCeftriaxone

Ceftriaxone

(mild allergy)

Seek expert advice

if severe allergy

Gram-negative rodsPiperacillin-tazobactamCiprofloxacin
None seen

Flucloxacillin

Vancomycin if MRSA suspected

Clindamycin