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Box 86.1

Disorders of Plasma Potassium Concentration

Plasma potassiumconcentration (mmol/L)ClassificationClinical and ECG features
>6.5Severe hyperkalaemia

Often asymptomatic. Muscle weakness may occur.

ECG: tall peaked T wave with shortened QT interval → Progressive lengthening of the PR interval and QRS duration → Sine wave QRS pattern → Ventricular standstill or fibrillation.

5.5–6.5Moderate hyperkalaemiaMay be asymptomatic.
5.0–5.5Mild hyperkalaemiaMay be asymptomatic.
3.5–5.0Normal range
3.0–3.5Mild hypokalaemiaMay be asymptomatic.
2.5–3.0Moderate hypokalaemiaECG: arrhythmias may occur, especially in patients with underlying cardiac disorders or taking antiarrhythmic drugs.
<2.5Severe hypokalaemia

Muscle necrosis may occur. Below 2 mmol/L there may be ascending paralysis, resembling Guillain-Barré syndrome. Ileus.

ECG: ST depression, reduced T wave amplitude, increased U wave amplitude.

Arrhythmias commonly occur: extrasystoles, atrial fibrillation, atrioventricular block, ventricular tachycardiac and fibrillation.