Intravenous Therapy for Severe Hypertension with Organ Damage
| Drug | Properties | Administration |
|---|---|---|
| Labetalol | Beta and alpha-adrenergic blocker | IV bolus: 10–20 mg over 1–2 min IV infusion: 1–8 mg/min (see text) |
| Esmolol | Short-acting beta-adrenergic blocker | IV bolus: 1 mg/kg over 30s IV infusion: 150–300μgm/kg/min (see text) |
| Isosorbide dinitrate | Nitric-oxide-mediated vasodilatation | IV infusion: 2–12 mg/h (see text) |
| Nicardipine | Dihydropyridine calcium channel blocker | IV infusion: 5–15 mg/h (see text) |
| Phentolamine | Short-acting, non-selective alpha-adrenergic blocker | IV bolus: 1 mg (response is maximal in 2–3 min and lasts 10–15 min) IV infusion |