Acute Fatty Liver of Pregnancy
Element | Comment | |
---|---|---|
Symptoms | Gradual onset of nausea, anorexia and malaise, severe vomiting and/or abdominal pain, polyuria, polydipsia | |
Examination findings | Hypertension and proteinuria usually mild, RUQ/epigastric discomfort, jaundice or ascites | |
Blood tests | Leukocytosis, coagulopathy, acute kidney injury, elevated transaminases, hypoglycaemia, elevated urate, elevated ammonia | |
Swansea criteria for diagnosis | The presence of six or more features (in the absence of an alternative diagnosis): | |
Vomiting | Leucocytosis | |
Abdominal pain | Elevated transaminases | |
Polydipsia/polyuria | Acute kidney injury | |
Encephalopathy | Elevated ammonia | |
Elevated bilirubin | Hypoglycaemia | |
Elevated urate | Coagulopathy | |
Ascites or bright liver on ultrasound | Microvesicular steatosis on liver biopsy |