Acute Fatty Liver of Pregnancy
| Element | Comment | |
|---|---|---|
| Symptoms | Gradual onset of nausea, anorexia and malaise, severe vomiting and/or abdominal pain, polyuria, polydipsia | |
| Examination findings | Hypertension and proteinuria usually mild, RUQ/epigastric discomfort, jaundice or ascites | |
| Blood tests | Leukocytosis, coagulopathy, acute kidney injury, elevated transaminases, hypoglycaemia, elevated urate, elevated ammonia | |
| Swansea criteria for diagnosis | The presence of six or more features (in the absence of an alternative diagnosis): | |
| Vomiting | Leucocytosis | |
| Abdominal pain | Elevated transaminases | |
| Polydipsia/polyuria | Acute kidney injury | |
| Encephalopathy | Elevated ammonia | |
| Elevated bilirubin | Hypoglycaemia | |
| Elevated urate | Coagulopathy | |
| Ascites or bright liver on ultrasound | Microvesicular steatosis on liver biopsy | |