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Table 95.3

Cellulitis: Assessment of Severity of Illness and Management

ClassFeaturesManagement
1

No significant systemic illness

No uncontrolled comorbidities

Oral antibiotic therapy (Table 95.4)

Outpatient management

2Significant systemic illness or comorbidity (e.g. peripheral arterial disease, morbid obesity)

IV antibiotic therapy (Table 95.4)

Outpatient/inpatient management*

3

Haemodynamic instability or delirium

Limb-threatening infection due to vascular compromise

Comorbidities that may interfere with response to therapy

IV antibiotic therapy (Table 95.4)

Inpatient management: level 1/HDU

4

Sepsis syndrome

Suspected necrotizing fasciitis

IV antibiotic therapy (Table 95.4)

Inpatient management: HDU/ICU

Reference: Eron LJ (2000) Infections of skin and soft tissue: outcomes of a classification scheme. Clinical Infectious Diseases 31, 287 (A432).

* Contraindications to outpatient management of patients with class 2 cellulitis:

  • Penicillin/cephalosporin allergy
  • Chronic liver or renal (CKD 4 or 5) disease
  • Immunosuppression
  • Facial or orbital cellulitis
  • Non-compliance with outpatient management likely
  • Unable to cope at home