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Table 103.10

Clinical Conditions Affecting the Response to Warfarin*

Increased anticoagulation

Impaired liver function

Heart failure

Acute kidney injury or chronic kidney disease

Malabsorptive states

Hyperthyroidism

Decreased anticoagulation

Hypothyroidism

Transfusion of whole blood or fresh frozen plasma

Diet high in vitamin K (green vegetables)

Hereditary resistance to warfarin

* Drug interactions with warfarin are common and can be serious. When starting or stopping a treatment in a patient taking warfarin, check the list in the British National Formulary for an interaction.