• Active internal bleeding
• Suspected aortic dissection
• Prolonged or traumatic cardiopulmonary resuscitation
• Recent head trauma or known intracranial neoplasm
• Trauma or surgery within the previous two weeks, which could be a source of rebleeding
• Diabetic haemorrhagic retinopathy or other haemorrhagic ophthalmic condition
• Pregnancy
• Recorded blood pressure >200/120 mmHg
• History of cerebrovascular accident known to be haemorrhagic

Relative

• Recent trauma or surgery (>2 weeks)
• History of chronic severe hypertension with or without drug therapy
• Active peptic ulcer
• History of cerebrovascular accident
• Known bleeding diathesis or current use of anticoagulants
• Significant liver dysfunction
• If there are one or more relative contraindications to thrombolytic therapy, you must weigh the risks and benefits of therapy for the individual before deciding whether or not it should be given