Dosing of Direct Oral Anticoagulants by Indication
| Dabigatran | RIvaroxaban | Apixaban | |
|---|---|---|---|
| Acute VTE | 150 mg BD following 5 days of LMWH/UFH | Day 1–21: 15 mg BD Day 22: 20 mg OD | Days 1–7: 10 mg BD Day 7: 5 mg BD |
| Prevention of recurrent VTE | 150 mg BD 110 mg BD* | 20 mg OD | 2.5 mg BD (after 6 months of 5 mg BD completed) |
| Thromboprophylaxis | 220 mg OD 150 mg OD* | 10 mg OD | 2.5 mg BD |
| Atrial fibrillation | 150 mg BD 110 mg BD* | 20 mg OD | 5 mg BD 2.5 mg BDy |
* A dose of 150 mg OD for thromboprophylaxis or 110 mg BD for AF/recurrent VTE should be considered in patients >75 years or patients with eGFR <50 mL/min.
y The reduced doses of apixaban and dabigatran in atrial fibrillation are recommded for patients with two of the following: age >60 years, weight<60kg, serum creatinine >133micromol/L.