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Table 36.10

Paracetamol Poisoning: Indications of Severe Hepatotoxicity

Rapid development of grade 2 encephalopathy (confused but able to answer questions)

Prothrombin time >20s at 24h, >45s at 48h or >50s at 72h

Increasing plasma bilirubin

Increasing plasma creatinine

Falling plasma phosphate

Arterial pH <7.3 more than 24h after ingestion