Epidemiology of Gout and Pseudogout
Gout | Pseudogout (calcium pyrophosphate dihydrate deposition (CPPD) disease) | |
---|---|---|
Age | Predominantly 3060 years, risk increases with advancing age | >60 years, risk increases in the elderly |
Sex | Male predominance, post-menopausal women, very rare in premenopausal women | Male: female ratio 50:50 |
Risk factors | Conditions which promote hyperuricaemia, due to overproduction or under-excretion of urate Overproduction of urate Genetic diseases:
Under-excretion of urate:
| Conditions that promote altered concentrations of calcium, inorganic pyrophosphate (PPi) and the solubility products of these ions Genetic diseases:
Metabolic conditions causing CPPD deposition:
|
Related comorbid conditions | Hypertension Diabetes mellitus Renal insufficiency Hypertriglyceridaemia Hypercholesterolaemia Obesity Anaemia | Hyperparathyroidism Haemochromatosis Hypomagnesaemia (Chapter 88) Hypophosphataemia (Chapter 89) Familial hypocalciuric hypercalcaemia |
Dietary factors | Foods rich in purines such as red meat and sea food | No clear dietary causes |