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Basics

Author(s): JohnKiel, DO, MPH and M. KyleSmoot, MD


Description

  • Acute low back pain is pain of <3 mo duration localized below the costal margin but above the inferior gluteal folds with or without leg pain.
  • Synonym(s): lumbar strain; lumbar sprain; lumbago; low back syndrome
  • Acute pain is felt in the low lumbar, lumbosacral, or sacroiliac region. It may be accompanied by sciatica, pain radiating down the distribution of the sciatic nerve.
  • Chronic low back pain is the same unremitting pain that has been present for >3 mo.

Epidemiology

  • The total costs of low back pain in the United States exceed $100 billion per year from direct and indirect costs.
  • It is the most common musculoskeletal reason for office visits to primary care providers.
  • Most common between the ages of 35 and 55 yr
  • ~1% of the U.S. population is chronically disabled because of back problems, and another 1% is temporarily disabled.

Incidence

  • 90% of people experience low back pain in their lifetime; 5–10% will develop chronic back pain.
  • Approximately 9.8% will develop sciatic nerve or radicular back pain.
  • Various authors have reported incidences of 16–22% in populations 8 to 14 yr of age.

Prevalence

  • Annual prevalence in the U.S. population is 15–20%.
  • Increases with age, peaking during the 6th decade of life

Risk-Factors

General Prevention

  • Exercise programs, posture training, body mechanics training, and weight loss have been advised.
  • U.S. Preventive Services Task Force has concluded that current evidence is not adequate to recommend for or against the routine use of interventions to prevent low back pain in adults.

Diagnosis

History

  • Initial history should focus on the patient’s age and pain characteristics (onset, duration, severity, quality, radiation, aggravating factors, alleviating factors).
  • Question patient about mechanism of injury and occupation.
  • Determine if serious underlying conditions (red flags) are responsible for the back pain: fracture (steroid use, trauma, menopausal status); infection (fever, intravenous [IV] drug use, adenopathy, immunosuppression); cancer (weight loss, adenopathy, previous cancer); cauda equina syndrome (bowel or bladder incontinence, saddle anesthesia, major limb motor weakness).
  • Assess psychological and socioeconomic problems.
  • The patient should be assessed for the following red flags:
    • Is patient <20 or >55 yr with no prior history of back pain?
    • Known or previous cancer? Assume bone metastasis until otherwise proven.
    • IV drug abuse? Assume spinal abscess if tender.
    • Is pain increased or unrelieved by rest? Is low back pain relieved by bed rest?
    • Is pain associated with fever, chills, or weight loss? Look for infection or tumor.
    • Loss of bowel or bladder control and/or caudal anesthesia? Look for cauda equina syndrome.

Physical Exam

  • Pain located below the costal margin but above the inferior gluteal folds
  • Possible radiation of pain to buttocks and lower extremity
  • Pain aggravated by movement and alleviated by rest
  • Limited range of motion of the lumbar spine
  • Paraspinal muscular spasm is common.
  • Assess severity of pain by observing the patient’s gait, posture, and demeanor.
  • Prior to examining the back, check the temperature, weight, skin, abdomen, pelvis, groin, peripheral pulses, and lymph nodes for pathology that may mimic spinal disease. A rectal exam should be performed to assess sphincter tone.
  • With the patient standing, assess stance, spinal curvature, range of motion, heel-walk, toe-walk, and squat. Locate area of maximal pain.
  • With patient sitting, assess patellar and Achilles deep tendon reflexes.
  • With the patient supine, assess the straight-leg raise and contralateral straight-leg raise, ankle and great toe dorsiflexion, hip range of motion, sacroiliac joint stability, muscle strength testing, and sensory testing.
  • With the patient in the prone position, assess buttock symmetry and perform femoral stretch test.
  • Pain in low back is exacerbated by movement and is often accompanied by focal muscle spasm in the lumbar extensors.
  • Patients prefer to stand in a semiflexed position and move slowly rather than sit motionless on the exam table.
  • Walk on heels (L4–L5) and then toes (S1–S2).
  • Assess back muscles for uncoordination or guarding (signs for spasm).
  • Straight-leg raising and crossed straight-leg raising (can suggest radicular etiology such as acute disc herniation)

Differential Diagnosis

Diagnostic Tests & Interpretation

  • In the absence of red flag symptoms, imaging can usually be delayed until 30 days after the initial assessment. This approach allows 90% of patients to recover spontaneously and avoids unneeded testing and procedures.
  • If symptoms persist >30 days, consider plain radiographs, computed tomography (CT) scan, magnetic resonance imaging (MRI), and bone scan.
  • If no red flags are identified in the history, then no imaging tests or laboratory tests are indicated.
  • If a red flag is identified, then proceed with diagnostic testing as indicated.

Treatment

  • Natural history of MBP, regardless of treatment: 33% resolve within 1 wk, 70% resolve within 1 mo, and 90–95% resolve within 3 mo.
  • Analgesia:
    • Acetaminophen for 2 wk (as effective as nonsteroidal anti-inflammatory drugs [NSAIDs] if given on schedule)
    • NSAIDs provide pain relief and allow early ambulation (caution for renal insufficiency, pregnancy, hypertension [HTN], gastrointestinal [GI] intolerance, history of gastric ulcers or bleeding).
    • Short-term tramadol on a schedule basis (50 mg TID)
    • Opioids have low-to-moderate evidence of short-term efficacy in chronic low back pain. The efficacy and safety of long-term use remains unproven (1). Caution should be taken before initiating opioids for chronic back pain given risk of dependence and abuse.
    • Muscle relaxants are effective in the management of nonspecific low back pain, but due to adverse effects, they should be used with caution.
  • Manipulative medicine:
    • Massage therapy may be effective for treatment of chronic back pain (2).
    • Passive therapies, such as spinal manipulation therapy, muscle energy, and traction have no proven benefit.
    • Physical therapy modalities including muscle energy, low-level laser therapy, and ultrasound have no evidence to support their use.
    • Exercise therapy appears to be slightly effective at decreasing pain and increasing function in adults with chronic low back pain (3).
    • The McKenzie method results in a decrease in and disability, but not pain, for acute low back pain (4).
    • There is evidence that yoga results in small to moderate improvements in back related function at 3 and 6 mo; it may be slightly more effective for pain (5).
    • Motor control exercise has low-to-moderate quality evidence that helps in chronic low back pain (6).
    • Combined chiropractic interventions slightly improved pain and disability for acute and subacute lower back pain (7).
    • Aquatic exercise appears to be beneficial in patients suffering from chronic back pain and pregnancy-related low back pain (8).
  • Systemic corticosteroids: no proven benefit and significant potential harm (avascular necrosis of the hip) (9)
  • Antidepressants: There is no evidence that antidepressants are more effect than placebo in the management of nonspecific low back pain (10). There is some evidence that tricyclic antidepressants may be similar in effectiveness to gabapentinoids (11).
  • Antiepileptic medications: Gabapentin and pregabalin use has shown nonsignificant improvement in pain compared to placebo (12). Topiramate is also slightly better than placebo for nonradicular back pain.
  • Behavioral therapy: There is moderate quality evidence that behavioral therapy can help individuals with chronic low back pain (13).
  • Herbal medicine: Low-to-moderate quality evidence shows that four topical herbal medicines may reduce pain in acute and chronic low back pain compared to placebo: cayenne, harpagoside, willow bark, and comfrey.
  • Injection therapy: There is conflicting evidence regarding the efficacy of prolotherapy. When used alone, it is not an effective treatment; however, when combined with other modalities, it may improve chronic low back pain (14). There is insufficient evidence to support any specific drug for injection (NSAIDS, corticosteroids, etc.) or location (disc, muscles, etc.).
  • Radiofrequency denervation: There is low-quality evidence supporting the use of radiofrequency denervation in patients with chronic low back pain (15).
  • Transcutaneous electrical nerve stimulation (TENS): There is no evidence from the small number of placebo-controlled trials to support the use of TENS (16).
  • Acupuncture: may have a favorable effect on self-reported pain and functional limitations in nonspecific chronic low back pain (17)
  • Insoles: There is strong evidence that insoles are ineffective for prevention of chronic back pain (18).
  • Lumbar support: There is moderate evidence that lumbar support is not more effective than no intervention in preventing low back pain (3).
  • Long term:
    • Systematic review of the literature of chronic low back pain concluded that individualized exercise therapy programs that incorporated stretching or strengthening and supervision may improve pain and function in chronic nonspecific low back pain (19).
    • Cochrane review of the literature added that there is evidence that a graded activity program improves absentee outcomes in subacute low back pain. In acute low back pain, exercise therapy is as effective as either no treatment or other conservative treatments (20).

Issues for Referral

Rapidly progressive neurologic deficits, symptoms of cauda equina syndrome or cord compression, acute vertebral collapse, suspicion of infection

Additional Therapies

  • Bed rest for 2 to 4 days may be required in patients with severe initial symptoms of sciatica. Prolonged bed rest (>4 days) should be avoided.
  • Patients should be advised to stay active because this speeds recovery and reduces time away from work. It takes twice as long to regain conditioning as it does to lose it.
  • Begin with low-stress aerobic activity such as walking, riding a bicycle, swimming, and eventually jogging.
  • After ~2 wk of general activity, specific conditioning exercises for trunk muscles may be helpful.
  • Physical therapy may be helpful during the 1st mo of symptoms. Goal of therapy is increasing function, not absence of pain.

Surgery/Other Procedures

  • Considered only when serious spinal pathology or nerve root dysfunction due to a herniated lumbar disc is detected
  • Patients with acute low back pain alone, without findings of serious conditions or significant nerve root compression, rarely benefit from surgery.
  • Surgery has not been proven to help back pain without radiculopathy (21).

Ongoing Care

Follow-up Recommendations

  • Begin walking as soon as possible.
  • Early osteopathic or chiropractic referral is often beneficial.
  • Early orthopedic or physical therapy referral is rarely indicated.

Additional Reading

Vijan S, Manaker S, Qaseem A. Noninvasive treatments for acute, subacute, and chronic low back pain. Ann Intern Med. 2017;167(11):835836.

References

  1. Chaparro LE, Furlan AD, Deshpande A, et al. Opioids compared with placebo or other treatments for chronic low back pain: an update of the Cochrane review. Spine (Phila Pa 1976). 2014;39(7):556563.
  2. Kumar S, Beaton K, Hughes T. The effectiveness of massage therapy for the treatment of nonspecific low back pain: a systematic review of systematic reviews. Int J Gen Med. 2013;6:733741.
  3. van Middelkoop M, Rubinstein SM, Verhagen AP, et al. Exercise therapy for chronic nonspecific low-back pain. Best Pract Res Clin Rheumatol. 2010;24(2):193204.
  4. Garcia AN, Costa Lda C, da Silva TM, et al. Effectiveness of back school versus McKenzie exercises in patients with chronic nonspecific low back pain: a randomized controlled trial. Phys Ther. 2013;93(6):729747.
  5. Cramer H, Lauche R, Haller H, et al. A systematic review and meta-analysis of yoga for low back pain. Clin J Pain. 2013;29(5):450460.
  6. Byström MG, Rasmussen-Barr E, Grooten WJ. Motor control exercises reduces pain and disability in chronic and recurrent low back pain: a meta-analysis. Spine (Phila Pa 1976). 2013;38(6):E350E358.
  7. Cherkin DC, Sherman K, Kahn J, et al. A comparison of the effects of 2 types of massage and usual care on chronic low back pain. Ann Intern Med. 2011;155(1):19.
  8. Baena-Beato , Artero EG, Arroyo-Morales M, et al. Aquatic therapy improves pain, disability, quality of life, body composition and fitness in sedentary adults with chronic low back pain. A controlled clinical trial. Clin Rehabil. 2014;28(4):350360.
  9. Chou R, Deyo R, Friedly J, et al. Systemic pharmacologic therapies for low back pain: a systematic review for an American College of Physicians clinical practice guideline. Ann Intern Med. 2017;166(7):480492.
  10. Kuijpers T, van Middelkoop M, Rubinstein SM, et al. A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain. Eur Spine J. 2011;20(1):4050.
  11. Dharmshaktu P, Tayal V, Kalra BS. Efficacy of antidepressants as analgesics: a review. J Clin Pharmacol. 2012;52(1):617.
  12. Atkinson JH, Slater MA, Capparelli EV, et al. A randomized controlled trial of gabapentin for chronic low back pain with and without a radiating component. Pain. 2016;157(7):14991507.
  13. Cherkin DC, Sherman KJ, Balderson BH, et al. Effect of mindfulness-based stress reduction vs cognitive behavioral therapy or usual care on back pain and functional limitations in adults with chronic low back pain: a randomized clinical trial. JAMA. 2016;315(12):12401249.
  14. Enke O, New HA, New CH, et al. Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis. CMAJ. 2018;190(26):E786E793.
  15. Leggett LE, Soril LJ, Lorenzetti DL, et al. Radiofrequency ablation for chronic low back pain: a systematic review of randomized controlled trials. Pain Res Manag. 2014;19(5):e146e153.
  16. Buchmuller A, Navez M, Milletre-Bernardin M, et al. Value of TENS for relief of chronic low back pain with or without radicular pain. Eur J Pain. 2012;16(5):656665.
  17. Lam M, Galvin R, Curry P. Effectiveness of acupuncture for nonspecific chronic low back pain: a systematic review and meta-analysis. Spine (Phila Pa 1976). 2013;38(24):21242138.
  18. Chuter V, Spink M, Searle A, et al. The effectiveness of shoe insoles for the prevention and treatment of low back pain: a systematic review and meta-analysis of randomised controlled trials. BMC Musculoskelet Disord. 2014;15:140.
  19. Searle A, Spink M, Ho A, et al. Exercise interventions for the treatment of chronic low back pain: a systematic review and meta-analysis of randomized controlled trials. Clin Rehabil. 2015;29(12):11551167.
  20. Macedo LG, Smeets RJ, Maher CG, et al. Graded activity and graded exposure for persistent nonspecific low back pain: a systematic review. Phys Ther. 2010;90(6):860879.
  21. Chou R, Baisden J, Carragee EJ, et al. Surgery for low back pain: a review of the evidence for an American Pain Society clinical practice guideline. Spine (Phila Pa 1976). 2009;34(10):10941109.

Clinical Pearls

  • Acute low back pain is the most common musculoskeletal complaint seen by primary care providers associated with a significant morbidity, health care cost, and missed work.
  • In the absence of red flags, imaging is generally not necessary on initial evaluation, and most patients will improve within 1 mo.
  • Initial conservative management includes minimal bed rest, nonopioid analgesia, muscle relaxants, and physical therapy.
  • Alternative, evidence-based treatments include exercise therapy, yoga, chiropractic interventions, aquatic exercise therapy, behavioral therapy, and herbal medicine.
  • There is no evidence supporting the use of corticosteroids, with increased risk of adverse events.