ATC Class:D07AC11
VA Class:DE200
Amcinonide is a synthetic fluorinated corticosteroid.
Amcinonide shares the actions of the other topical corticosteroids and is used for the relief of the inflammatory manifestations of corticosteroid-responsive dermatoses. Based on clinical studies in patients with various dermatoses and on vasoconstrictor assay, the anti-inflammatory activity of 0.1% amcinonide cream is similar to that of 0.1% betamethasone valerate cream, 0.1% triamcinolone acetonide cream, or 0.025% fluocinolone acetonide cream.
Topical amcinonide cream or ointment are applied sparingly in a thin film to the affected area 2 or 3 times daily. The cream is rubbed in gently and thoroughly. Amcinonide lotion, which may be particularly useful for use on the scalp and hairy areas of the trunk and extremities, is applied and rubbed thoroughly into the affected area twice daily. Following application of the lotion, the affected area should be protected (i.e., from washing, clothing, or rubbing) until the lotion has dried. Occlusive dressings may be used for severe or resistant dermatoses.
Amcinonide is a synthetic fluorinated corticosteroid. Amcinonide occurs as a white solid and is insoluble in water.
Amcinonide cream should be stored in well-closed containers at a temperature less than 40°C, preferably between 15-30°C; freezing should be avoided. Amcinonide lotion and ointment should be stored at 15-30°C; freezing of the lotion should be avoided.
Additional Information
For further information on chemistry, pharmacology, absorption, uses, cautions, methods of application, and use of occlusive dressings in therapy with amcinonide, see the Topical Corticosteroids General Statement 84:06.08.
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
---|---|---|---|---|
Topical | Cream | 0.1%* | Cyclocort® (with benzyl alcohol 2% and Aquatain® hydrophilic base) | Astellas |
Lotion | 0.1%* | Cyclocort® (with benzyl alcohol 1% w/w and Aquatain® hydrophilic base) | Astellas | |
Ointment | 0.1% | Cyclocort® (with benzyl alcohol and propylene glycol) | Astellas |
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name