ATC Class:D07AC10

VA Class:DE200

AHFS Class:

• Corticosteroids 84:06.08

Generic Name(s):

• Diflorasone Diacetate

Diflorasone diacetate is a synthetic fluorinated corticosteroid.

Diflorasone diacetate shares the actions of the other topical corticosteroids and is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Topical diflorasone diacetate cream is applied sparingly in a thin film and rubbed gently into the affected area 2-4 times daily; the emollient cream preparation (Fluorone E^®) and the ointments, including the enhanced-potency preparation (Psorcon^®), are applied 1-3 times daily. Occlusive dressings may be used for severe or resistant dermatoses. Although the manufacturer of Psorcon^® states that occlusive dressings also may be used with this enhanced-potency preparation, some clinicians recommend that occlusion generally be avoided with this preparation until additional safety data are available.

Chemistry and Stability

Chemistry

Diflorasone diacetate is a synthetic fluorinated corticosteroid. The drug occurs as a white to buff-colored powder and is insoluble in water.

Stability

Diflorasone diacetate preparations should be stored in well-closed containers at 15-30°C.

Additional Information

For further information on chemistry, pharmacology, absorption, uses, cautions, methods of application, and use of occlusive dressings in therapy with diflorasone diacetate, see the Topical Corticosteroids General Statement 84:06.08.