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Introduction

VA Class:GA204

ATC Class:A06AB05

AHFS Class:

Generic Name(s):

Castor oil, a stimulant laxative, is a fixed oil obtained from the seeds of Ricinus communis .

Dosage and Administration

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Administration !!navigator!!

Castor oil is administered orally. Emulsions or aromatic preparations somewhat mask the disagreeable taste of castor oil. Containers of castor oil emulsion should be shaken before using, and the emulsion may be mixed with 120-240 mL of water, milk, fruit juice, or soft drink before administration.

Dosage !!navigator!!

The usual adult dose of castor oil for constipation is 15 mL; however, castor oil usually should be reserved for total colonic evacuation, such as prior to surgery or radiologic, sigmoidoscopic, or proctoscopic procedures. For these purposes, the usual dose of castor oil is 15-60 mL for adults and children 12 years of age and older, 5-15 mL for children 2-11 years of age, or 1-5 mL for children younger than 2 years of age, administered as a single dose about 16 hours before the surgery or procedure. To prepare for colonic surgery or radiologic, sigmoidoscopic, or proctoscopic procedures, the patient should receive a residue-free diet one day before the surgery or procedure and a cleansing rectal enema (e.g., tap water, soap suds, saline laxative, bisacodyl) on the day of the examination. Additionally, standardized senna fruit extract may be administered 4 hours after castor oil.

Other Information

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Pharmacokinetics

The extent of GI absorption of castor oil is unknown. In the small intestine, castor oil is hydrolyzed by pancreatic lipase to its active principle, ricinoleic acid. Ricinoleic acid is absorbed to a small extent and subsequently metabolized like other fatty acids. Loose bowel movements usually occur within 2-3 hours following oral castor oil administration.

Chemistry and Stability

Chemistry !!navigator!!

Castor oil, a stimulant laxative, is a fixed oil obtained from the seeds of Ricinus communis. The drug, which is an ester of ricinoleic acid, occurs as a pale yellowish or almost colorless, transparent, viscid liquid having a faint, mild odor and a bland, characteristic taste. The oil has a specific gravity of 0.957-0.961. Castor oil is soluble in alcohol. Aromatic castor oil is a solution of castor oil in alcohol containing suitable flavoring agents. Aromatic castor oil contains not less than 95% castor oil and not more than 4% alcohol.

Stability !!navigator!!

To avoid rancidity, castor oil should not be exposed to temperatures above 40°C. Castor oil emulsions should be protected from freezing.

Additional Information

For further information on pharmacology, uses, cautions, drug interactions, and dosage and administration of castor oil, see the Cathartics and Laxatives General Statement 56:12.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Castor Oil

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Oil

95% w/v*

Purge®

Fleming

Suspension

36.4% w/w

Neoloid® (with propylene glycol)

Kenwood

95% w/v*

Emulsoil®

Paddock

Purge®

Fleming

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Castor Oil Aromatic

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Oil

Castor Oil Aromatic

Roxane

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Copyright

AHFS® Drug Information. © Copyright, 1959-2024, Selected Revisions January 1, 2002. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, MD 20814.