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Introduction

VA Class:TN101

AHFS Class:

Generic Name(s):

Invert sugar is a carbohydrate caloric agent consisting of an equimolar mixture of dextrose and fructose.

Uses

Invert sugar solutions are used as a source of calories and water for hydration.

Fat emulsions generally are used in combination with amino acid and dextrose injections during parenteral nutrition. Dosage, route of administration (peripheral or central IV), and concomitant infusion of protein and other nonprotein calories depend on various factors including nutritional and metabolic status of the patient, anticipated duration of parenteral nutritional support, and tolerance of the veins.

For further information on chemistry and stability, pharmacology, uses, cautions, and dosage and administration of fat emulsions, specialized references on nutritional support and the manufacturers'; labeling should be consulted.

Dosage and Administration

Invert sugar is administered by IV infusion. For adults, the usual dosage is 1-3 L of a 10% solution daily.

For further information on chemistry, pharmacology, uses, cautions, and dosage and administration of invert sugar, specialized references and the manufacturers'; labeling should be consulted. See also Dextrose 40:20.

Other Information

Pharmacology

Invert sugar shares the actions of dextrose and fructose; any purported advantage of invert sugar over dextrose would result from the fructose component.

Chemistry

Invert sugar is an equimolar mixture of dextrose and fructose. Commercially available invert sugar injections have a pH of 3.7-4. Each gram of invert sugar provides approximately 4 calories.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Invert Sugar Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

Injection, for IV infusion only

Invert sugar is commercially available in combination with electrolytes for IV administration.

Copyright

AHFS® Drug Information. © Copyright, 1959-2022, Selected Revisions January 1, 2006. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, MD 20814.