Adult Dosing

Heartburn, acid indigestion, sour stomach, upset stomach

• 10-20 mL PO between meals, at bedtime or PRN
• Max: 45 mL PO qd for not more than 2 wks

Pediatric Dosing

Heartburn, acid indigestion, sour stomach, upset stomach

Children <12 yrs

• Consult a physician

Children >12 yrs

• 10-20 mL PO between meals, at bedtime or PRN
• Max: 45 mL PO qd for not more than 2 wks

[Outline]

• Adult Dosing
• Pediatric Dosing

• Relief of heartburn, acid indigestion, sour stomach, and upset stomach

• Hypersensitivity to any of the ingredients of the product
• Kidney failure
• Colostomy/ileostomy
• GI obstruction
• High dosage in pregnancy

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined
• Renal failure: Contraindicated

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Prior to prescribing the drug, evaluate for kidney disease. Do not use in patients on magnesium-restricted diet
• Avoid use of concomitant prescription drug as antacids may interact with certain prescription drugs
• Discontinue therapy and consult a clinician if symptoms persist for more than 14 days
• Seek medical assistance or contact a Poison Control Center immediately if accidental overdose occurs

Cautions: Use cautiously in

• Renal impairment
• Volume depletion
• GI bleed
• GI obstruction

Supplemental Patient Information

• Advise patients to keep this drug out of reach of children

Pregnancy Category:NR

Breastfeeding: No published information is available on use of aluminum hydroxide, antacid therapy in nursing mothers. Additional intake of this mineral by a nursing mother is unlikely to surpass that found in other infant foods. Oral absorption of aluminum and magnesium is poor. Hence, antacid use during breastfeeding is acceptable and no special precautions are required. This information is based upon Lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 6 December 2011).

• GI: Abdominal pain, constipation, diarrhea, nausea, vomiting
• MUSC: Osteomalacia
• NEURO: Encephalopathy
• METABOLIC: Hypermagnesemia, hypophosphatemia, dehydration
• MISC: Aluminum intoxication

Aluminum hydroxide

• Antacid; neutralizes hydrochloric acid in gastric secretions; also inhibits the action of pepsin by increasing the pH and via adsorption
• 17-30% systemic absorption
• Not metabolized
• Excreted in feces and urine
• Half-life: Unknown

Magnesium hydroxide

• Antacid/laxative; neutralizes gastric acid; causes water retention in stool, causing peristalsis
• Poorly absorbed
• Metabolism: Unknown
• Excretion: Urine, feces
• Half-life: Unknown

US Trade Name(s)

• Mylanta Ultimate Strength Liquid

US Availability

Mylanta Ultimate Strength Liquid

• OTC SUSP: [500 mg/500 mg]/5 mL

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• Mucogel
• Maalox

UK Availability

Mucogel, Maalox

• SUSP: [220 mg/195 mg]/5 mL

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Gastrointestinal

Antacids