Adult Dosing

Bacterial Vaginosis

Cleocin

• Pregnant patients: 1 applicatorful (5 g) PV qhs x 7 days
• Non-pregnant patients: 1 applicatorful (5 g) PV qhs x 3 or 7 days; alt: 100 mg vaginal supp qhs x 3 days

Clindesse

• Post menarchal females:1 applicatorful (5 g) PV x 1

ClindaMax

• Pregnant patients: 1 applicatorful (5 g) PV qhs x 7 days
• Non-pregnant patients: 1 applicatorful (5 g) PV qhs x 3 or 7 days; alt: 100 mg vaginal supp qhs x 3 days

Pediatric Dosing

• Safety and effectiveness in pediatric population has not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Bacterial vaginosis in adults and adolescents (post puberty)

• Hypersensitivity to clindamycin, lincomycin or any of the ingredients of the product
• Hx of regional enteritis or ulcerative colitis
• Pseudomembranous colitis

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Pseudomembranous colitis, ranging in severity from mild to life-threatening colitis has been reported with oral and parenteral clindamycin. Consider this diagnosis in patients who present with diarrhea subsequent to the administration of clindamycin, even when administered by the vaginal route
• Overgrowth of nonsusceptible organisms in the vagina has occurred. May cause Candida vaginitis.
• Clindamycin cream contains mineral oil that may weaken latex/rubber products such as condoms/vaginal contraceptive diaphragms. Use of such products within 72 hours following treatment with Vaginal Cream 2%, is not recommended
• It can be used to treat non-pregnant women and pregnant women during the second and third trimester
• Do not use other vaginal products (tampons/douches) during treatment with clindamycin (vaginal)

Pregnancy Category:B

Breastfeeding: It is not known if clindamycin is excreted in human milk following vaginal application. Though 30% of a vaginal dose is absorbed, it is unlikely to cause infant adverse events. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT). This drug is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 last accessed 12 November 2010)

• GI: Nausea, vomiting, diarrhea, abdominal cramps
• CNS: Headache
• DERM: Rash, urticaria
• LOCAL: Vaginal discharge, vulvovaginal irritation/candidiasis

• Antibacterial; binds to the 50S ribosomal subunit; inhibits bacterial protein synthesis and affects the process of peptide chain initiation
• 30% absorbed following vaginal application
• Metabolized by liver; CYP450: unknown
• Excretion: urine; feces
• Half-life: 11 hrs

US Trade Name(s)

• ClindaMax
• Cleocin
• Clindesse

US Availability

Clindamycin (generic)

• CRE: 2%

ClindaMax

• CRE: 2%

Cleocin

• CRE: 2%
• SUPP: 100 mg

Clindesse

• CRE: 2%

Canadian Trade Name(s)

• Dalacin

Canadian Availability

Dalacin

• CRE: 2%

UK Trade Name(s)

• Dalacin

UK Availability

Dalacin

• CRE: 2%

Australian Trade Name(s)

• Dalacin V Cream

Australian Availability

Dalacin V Cream

• CRE: 2%

[Outline]

Antimicrobials

Antibiotics

Lincomycins (Clindamycin)

Infectious Disease

Antibiotics

Lincomycins (Clindamycin)

Pricing data from www.DrugStore.com in U.S.A.

• Cleocin 2 % CREA [Tube] (PFIZER U.S.)
  40 % = $90.29
  120 % = $262.46
• Clindamax 2 % CREA [Tube] (PHARMADERM)
  40 % = $59.99
  120 % = $169.97
• ClindaMax 1 % LOTN [Bottle] (PHARMADERM)
  60 % = $75.4
  180 % = $211.71
• Cleocin 100 MG SUPP [Box] (PFIZER U.S.)
  3 mg = $80.83
  9 mg = $226.75

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.