Adult Dosing

Mydriasis and cycloplegia for refraction

• 1-2 gtts (2 or 5% solution) in eye(s) immediately before procedure, repeat in 5-10 minutes if necessary

Acute inflammatory conditions of the uveal tract

• 1-2 gtts (2 or 5% solution) in eye(s) bid-tid; may give 1-2 gtts q3-4 hrs if needed

Pediatric Dosing

Mydriasis and cycloplegia for refraction

• 1 gtt (2% solution) in eye(s) immediately before procedure, repeated in 10-minute intervals if necessary

Acute inflammatory conditions of the uveal tract

• 1 gtt (2% solution) in eye(s) bid-tid

• To produce mydriasis and cycloplegia for refraction
• Management of acute inflammatory conditions of the uveal tract

• Hypersensitivity to any of the ingredients or class of the product
• Primary glaucoma or a predisposition to glaucoma

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Excessive use of drug in children or susceptible individuals may produce systemic antimuscarinic effects
• Prolonged use may cause local irritation characterized by follicular conjunctivitis, vascular congestion, edema, exudate, and eczematoid dermatitis
• Advise patients to discontinue the drug and contact their physician if signs or symptoms of sensitivity or increase in irritation occurs during treatment
• Prior to initiation of therapy, determine the depth of the angle of the anterior chamber so as to prevent induction of angle-closure glaucoma in susceptible patients

Cautions: Use cautiously in

• Infants
• Young children

Pregnancy Category:C

Breastfeeding: Prolonged use of homatropine hydrobromide might reduce milk production, but an ophthalmic dose is unlikely to interfere with breastfeeding. During prolonged use, observe for signs of decreased lactation such as insatiety, poor weight gain (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 16 February 2011).

• EENT: Increase in IOP, blurred vision, photophobia, ocular irritation and burning, follicular conjunctivitis, vascular congestion, hyperemia, eyelid edema, exudate, eczematoid dermatitis
• CNS: Seizures, confusion
• PSYCHIATRY: Psychosis, hallucinations, behavioral disturbances
• CV: Tachycardia, hypotension
• RESP: Respiratory depression
• GI: Abdominal distention in infants

• Anticholinergic; blocks the responses of the sphincter muscle of the iris and ciliary muscle of the lens to cholinergic stimulation, thereby producing mydriasis and cycloplegia
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• Isopto homatropine (Discontinued)

US Availability

homatropine (generic)

• OPTH SOLN: 5%

Isopto homatropine

• OPTH SOLN: 2%
• OPTH SOLN: 5%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• Only generic available

Australian Availability

isopto homatropine (generic)

• OPTH SOLN: 2%
• OPTH SOLN: 5%

Ophthalmic

Ophthalmic Diagnostic Agents

Anticholinergic

Pricing data from www.DrugStore.com in U.S.A.

• Isopto Homatropine 2 % SOLN [Bottle] (ALCON VISION)
  5 % = $43.61
  15 % = $103.55
• Isopto Homatropine 5 % SOLN [Bottle] (ALCON VISION)
  5 % = $50.13
  15 % = $117.67

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.