Adult Dosing

Allergic rhinitis

• TABS, SOLN: 4-8 mg PO tid-qid
• ESUSP: 7.5 mL to 20 mL (6 to 16 mg) PO every 12 hours

Urticaria

• TABS, SOLN: 4-8 mg PO tid-qid
• ESUSP:7.5 mL to 20 mL (6 to 16 mg) PO every 12 hours

Allergic reactions

• TABS, SOLN: 4-8 mg PO tid-qid
• ESUSP:7.5 mL to 20 mL (6 to 16 mg) PO every 12 hours

Pediatric Dosing

Allergic rhinitis

• TABS, SOLN
• 2-3 yrs: 2 mg PO tid-qid
• 3-6 yrs: 2-4 mg PO tid-qid
• >6 yrs: 4-6 mg PO tid-qid

• ESUSP
• 2-3 years: 3.75 mL to 5 mL (3 to 4 mg) PO every 12 hours
• 4-5 years: 3.75 mL to 10 mL (3 to 8 mg) PO every 12 hours
• 6-11 years: 7.5 mL to 15 mL (6 to 12 mg) PO every 12 hours
• 12 years: 7.5 mL to 20 mL (6 to 16 mg) PO every 12 hours

Urticaria

• TABS, SOLN
• 2-3 yrs: 2 mg PO tid-qid
• 3-6 yrs: 2-4 mg PO tid-qid
• >6 yrs: 4-6 mg PO tid-qid

• ESUSP
• 2-3 years: 3.75 mL to 5 mL (3 to 4 mg) PO every 12 hours
• 4-5 years: 3.75 mL to 10 mL (3 to 8 mg) PO every 12 hours
• 6-11 years: 7.5 mL to 15 mL (6 to 12 mg) PO every 12 hours
• 12 years: 7.5 mL to 20 mL (6 to 16 mg) PO every 12 hours

Allergic reactions

• TABS, SOLN
• 2-3 yrs: 2 mg PO tid-qid
• 3-6 yrs: 2-4 mg PO tid-qid
• >6 yrs: 4-6 mg PO tid-qid

• ESUSP
• 2-3 years: 3.75 mL to 5 mL (3 to 4 mg) PO every 12 hours
• 4-5 years: 3.75 mL to 10 mL (3 to 8 mg) PO every 12 hours
• 6-11 years: 7.5 mL to 15 mL (6 to 12 mg) PO every 12 hours
• 12 years: 7.5 mL to 20 mL (6 to 16 mg) PO every 12 hours

[Outline]

• Adult Dosing
• Pediatric Dosing

• Symptomatic treatment for allergic rhinitis, urticaria, and allergic reactions

• Hypersensitivity to any of the ingredients of the product
• Hypersensitivity to monoamine oxidase inhibitor therapy
• Patients <2 yrs of age
• Nursing mothers
• Acute asthma attack
• Narrow-angle glaucoma
• Peptic ulcer
• Severe coronary artery disease
• Severe hypertension
• Urinary retention
• Potassium chloride
• Potassium citrate
• Sodium phosphate/potassium phosphate
• Urinary acidifiers

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Carbinoxamine maleate exhibits atropine-like action
• Avoid using for treatment of lower respiratory tract symptoms, including asthma
• This drug is associated with diminishing mental alertness in children and producing excitation in young children
• Produces dizziness, sedation, and hypotension in geriatrics (60 yrs)

Cautions: Use cautiously in

• Cardiovascular disease
• Hypertension
• GI obstruction
• Peptic ulcer disease
• Angle closure glaucoma
• Increased intraocular pressure
• Hyperthyroidism
• Asthma
• COPD
• Lower respiratory tract symptoms
• Prostatic hypertrophy
• Use of CNS depressant
• Patients <6 yrs
• Geriatrics

Supplemental Patient Information

• Advise patients to avoid alcoholic beverages while taking this drug and also avoid taking sedatives or tranquilizers
• Warn patients to exercise caution when driving a motor vehicle or operating machinery

Pregnancy Category:C

Breastfeeding: Lower occasional doses of are probably acceptable during breastfeeding. Higher doses or more long term use is associated with drowsiness and other effects in the infant and decreases the milk supply, particularly in combination with a sympathomimetic or before lactation is well established. This information is based upon Lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 18 February 2011). According to manufacturer’s data higher risk exists in infants, newborns and premature in particular and use of carbinoxamine maleate is contraindicated in nursing mothers.

• CV: Hypotension, palpitations, tachycardia, extrasystoles
• HEMA: Hemolytic anemia, thrombocytopenia, agranulocytosis
• CNS: Sedation, sleepiness, dizziness, disturbed coordination, fatigue, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, euphoria, vertigo, hysteria, convulsions, headache
• EENT: Blurred vision, diplopia, tinnitus, acute labyrinthitis, dryness of nose and throat
• NEURO: Paresthesia, neuritis
• GI: Epigastric distress, anorexia, nausea, vomiting, diarrhea, dry mouth, constipation
• GU: Urinary frequency, difficult urination, urinary retention, early menses
• DERM: Urticaria, rash, photosensitivity, excessive perspiration
• RESP: Thickenings of bronchial secretions, tightness of chest and wheezing, nasal stuffiness
• MISC: Chills, anaphylactic shock

• Antihistamines; antagonizes central and peripheral H1 receptors
• Metabolism: Unknown; CYP450: Unknown
• Excretion; Unknown
• Half life: Unknown

US Trade Name(s)

• Palgic
• Arbinoxa
• Karbinal ER

US Availability

carbinoxamine (generic)

• TABS: 4 mg
• SOLN: 4 mg/5 mL

Palgic

• TABS: 4 mg
• SOLN: 4 mg/5 mL

Arbinoxa

• TABS: 4 mg
• SOLN: 4 mg/5 mL

Karbinal ER

• ESUSP: 4 mg/5 mL

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Allergy & Immunology

Antihistamines

Pricing data from www.DrugStore.com in U.S.A.

• Arbinoxa 4 MG/5ML LIQD [Bottle] (HAWTHORN PHARMACEUTICALS)
  473 5ml = $75.99
  1419 5ml = $215.98
• Palgic 4 MG TABS [Bottle] (PAM LABORATORIES)
  60 mg = $57.76
  180 mg = $148.2
• Arbinoxa 4 MG TABS [Bottle] (HAWTHORN PHARMACEUTICALS)
  100 mg = $75.99
  300 mg = $215.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Drug Name: Palgic 4 MG Oral Tablet

Ingredient(s): Carbinoxamine

Imprint: PAL;4

Color(s): White

Shape: Round

Size (mm): 7.00

Score: 2

Inactive Ingredient(s): anhydrous lactose / magnesium stearate / microcrystalline cellulose / sodium starch glycolate

Drug Label Author:
Pamlab, L.L.C.

DEA Schedule:
Non-Scheduled