Adult Dosing

Corneal cystine crystal accumulation in patients with cystinosis

• Instill one drop in each eye, every waking hour

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Corneal cystine crystal accumulation in patients with cystinosis

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic adjustment: Dose adjustments not defined

• For topical ophthalmic use only
• Do not touch the eyelids or surrounding areas with the dropper tip of the bottle to minimize the risk of contaminating the dropper tip and solution
• Oral administration of cysteamine has been associated with benign intracranial hypertension (or pseudotumor cerebri) which has resolved with diuretic therapy
• Concurrent oral cysteamine therapy has been associated with reports of benign intracranial hypertension
• Cysteamine contains benzalkonium chloride, which may be absorbed by soft contact lenses. Contact lenses should be removed prior to application of solution and may be reinserted 15 minutes following its administration

Pregnancy Category:C

Breastfeeding: It is not known whether cysteamine is excreted in human milk. Because of the potential for possible serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

• EENT: Sensitivity to light, redness, eye pain/irritation, visual field defects
• CNS: Headache, pseudotumor cerebri

• Cystine-depleting agent; prevents the accumulation of intracellular cystine by converting cystine to cysteine and cysteine-cysteamine mixed disulfides and reduces corneal cystine crystal accumulation
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• Cystaran

US Availability

Cystaran

• OPH SOLN: 0.44%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Ophthalmic

Other Ophthalmics

Cystine-depleting Agent