Adult Dosing
Type 2 diabetes mellitus (NIDDM)
Immediate release
- 5 mg PO qd, 30 min before breakfast; 2.5 mg PO qd in geriatric patients and patients with liver disease
- Titrate in increments of 2.5-5 mg/day at intervals of 3-7 days
- Usual: 5-25 mg PO qd, MAX: 40 mg/day
- Note: Divide when total daily doses >15 mg
Extended release
- Start 5 mg PO qd with breakfast
- Titrate dose depending on response determined by HbA1c levels measured q3mo
- Usual: 5-10 mg PO qd
- MAX: 20 mg/day
- Note: Do not cut/crush/chew ER form
Pediatric Dosing
- Safety and effectiveness in pediatric population have not been established
[Outline]
- Administration of oral hypoglycemic drugs is associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin
- Use with caution in patients with renal and hepatic impairment. If hypoglycemia occurs in such patients, appropriate management should be instituted
- Hypoglycemia is the most common adverse reaction of sulphonylurea therapy. Hypoglycemia is more likely to occur when caloric intake is deficient, after severe or prolonged exercise, or when more than one glucose-lowering drug is used
- Monitor blood and urine glucose periodically
- Use in pts with G6PD deficiency may cause hemolytic anemia, Non-sulfonylurea alternative should be considered
Cautions: Use cautiously in
- Severe renal impairment
- Hepatic impairment
- Hypoglycemia
- Adrenal insufficiency
- Infection
- Stress
- Illness
- Change in diet or activity
- Changes in dose of other hypoglycemic medications
- Malnutrition
- G6PD deficiency
- Elderly patients
- Hypersensitivity to sulphonamides
Pregnancy Category:C
Breastfeeding: Discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. If the drug is discontinued and control by diet is inadequate, Insulin therapy may be considered. Limited data indicate that the levels in breast milk are low. However, an alternate better studied drug may be preferred, especially while nursing a newborn or preterm infant. Monitoring of the breastfed infant's blood glucose. This information is based upon lactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 3 June 2010).
Pricing data from www.DrugStore.com in U.S.A.
- Glucotrol XL 2.5 MG TB24 [Bottle] (PFIZER U.S.)
30 mg = $32.99
90 mg = $71.97 - GlipiZIDE 10 MG TABS [Bottle] (WATSON LABS)
90 mg = $19.5
180 mg = $21.99 - GlipiZIDE 5 MG TABS [Bottle] (WATSON LABS)
100 mg = $22.42
200 mg = $23.65 - Glucotrol XL 5 MG TB24 [Bottle] (PFIZER U.S.)
30 mg = $33.59
90 mg = $76.62 - Glucotrol 5 MG TABS [Bottle] (PFIZER U.S.)
60 mg = $43.99
180 mg = $125.97 - Glucotrol 10 MG TABS [Bottle] (PFIZER U.S.)
60 mg = $81.89
180 mg = $230.97 - GlipiZIDE 10 MG TB24 [Bottle] (WATSON LABS)
30 mg = $23.99
90 mg = $69.97 - Glucotrol XL 10 MG TB24 [Bottle] (PFIZER U.S.)
30 mg = $48.99
90 mg = $129.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
