Adult Dosing

Continuous renal replacement therapy (CRRT)

• One 240 mL vial should be diluted in 3 L of sterile Water to make 3.24 L of infusate solution for injection

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Used as a replacement solution to replace water and to correct electrolytes and acid-base imbalance in Continuous Renal Replacement Therapy (CRRT)

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Therapy may cause serious fluid imbalance and electrolyte, acid-base, and glucose disturbances. Monitor patient’s hemodynamic status, and fluid, electrolyte, glucose and acid-base balance throughout the procedure

Pregnancy Category:C

Breastfeeding: According to manufacturer data therapy is not expected to harm a nursing infant.

• N/A

Magnesium chloride

• Electrolyte replenisher; it is an important activator of many enzyme systems
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

Sodium bicarbonate

• Alkalizing agent/Antacid; increases plasma bicarbonate, buffers excess hydrogen ion concentration, and raises blood pH, thereby reversing the clinical manifestations of acidosis; also increases the excretion of free bicarbonate ions in the urine, causing alkalinization of urine. Neutralizes or buffers existing quantities of stomach acid, thereby increasing the stomach pH
• Metabolism: Unknown
• Excreted in urine
• Half-life: Unknown

Sodium chloride

• Ionic compound; it balances electrolyte and body fluid levels
• Mainly absorbed by GI tract
• Extensively excreted in urine and small amounts in sweat, feces, tears and saliva
• Half-life: Unknown

US Trade Name(s)

• Normocarb HF 25
• Normocarb HF 35

US Availability

Normocarb HF 25

• SOLN for INJ: [0.21g/2.8g/9.07g]/100ML (240 mL vial)

Normocarb HF 35

• SOLN for INJ: [0.21g/3.97g/8.3g]/100ML (240 mL vial)

Canadian Trade Name(s)

• Normocarb HF 25
• Normocarb HF 35

Canadian Availability

Normocarb HF 25

• SOLN for INJ: [2.06 G/28.35 G/90.73 G]/L

Normocarb HF 35

• SOLN for INJ: [2.06 G/39.7 G/82.84 G]/L

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Nephrologic

Dialysis Agents

Miscellaneous Agents