Adult Dosing

Allergic conjunctivitis

• Instill one gtt in each affected eye bid

Pediatric Dosing

Allergic conjunctivitis

• Safety and effectiveness in children <2 yrs have not established
• >2yrs: Instill one gtt in each affected eye bid
• Note: Efficacy in <10 yrs of pediatrics is established from clinical trials conducted in >10 yr pediatric patients

• Allergic conjunctivitis

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustments

• Renal impairment: No dose adjustments

Hepatic Dose Adjustments

• Hepatic impairment: No dose adjustments

See Supplemental Patient Information

• Do not use to treat contact lens-related irritation
• Remove contact lenses prior to instillation
• Use cautiously in nursing mothers

Supplemental Patient Information

• Care should be taken not to touch the dropper to the eyelids or surrounding areas, to minimize the contamination

Pregnancy Category:C

Breastfeeding: Not expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breast milk, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 15 November 2010). Manufacturer advises caution while using in nursing mothers.

• EENT: Mild taste following instillation, eye irritation, nasopharyngitis
• CNS: Headache

• H1 receptor antagonist; acts by inhibiting the release of histamine from mast cells
• Minimal systemic absorption
• Metabolized by liver; CYP450: minimal
• Excreted in urine (75-90% unchanged)

US Trade Name(s)

• Bepreve

US Availability

Bepreve

• SOLN: 1.5%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

Ophthalmic

Antihistamine

Pricing data from www.DrugStore.com in U.S.A.

• Bepreve 1.5 % SOLN [Bottle] (ISTA PHARMACEUTICALS)
  5 % = $135.99
  15 % = $388.96
• Bepreve 1.5 % SOLN [Bottle] (ISTA PHARMACEUTICALS)
  10 % = $236.47
  30 % = $664.48

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.