Renal Dose Adjustment
- Renal impairment: Dose adjustments not defined
Hepatic Dosage Adjustment
- Hepatic impairment: Dose adjustments not defined
- Syncope, sometimes resulting in falling with injury or sometimes associated with tonic-clonic movements and other seizure-like activity, has been reported following vaccination with human papillomavirus vaccine (quadrivalent), monitor the patient 15 minutes after administration and restore cerebral perfusion by maintaining a supine or trendelenburg position
- Prefilled syringe has a tip cap containing natural rubber latex which can cause allergic reaction in latex sensitive individuals
- Review the immunization history for possible vaccine hypersensitivity and previous vaccination-related adverse reactions prior to administration of human papillomavirus vaccine (bivalent). In case of anaphylactic reactions, keep appropriate medical treatment and supervision readily available
- Human papillomavirus vaccine (bivalent) does not provide protection against disease from vaccine and non-vaccine HPV types to which a woman has previously been exposed through sexual activity
Cautions: Use cautiously in
- Immunocompromised individuals
- Immunosuppressant use
- Hypersensitivity to latex
Pregnancy Category:B
Breastfeeding: Vaccines given to a nursing mother do not affect the safety of breastfeeding for mothers or infants as stated by the Centers for Disease Control and Prevention. Maternal vaccination with human papillomavirus vaccine is not a contraindication to breastfeeding. This data is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 11 Jan 2011). As per manufacturer data, excretion of vaccine induced antibodies in human milk has not been studied. As many drugs are excreted in human milk manufacturer advises caution when administering to a nursing woman.
