Adult Dosing

Constipation; evacuation of colon

• 1 glassful (approximately 150-300 ml) PO once, may repeat PRN

Pediatric Dosing

Constipation; evacuation of colon

• Child 6-12 yrs: 0.5 mL/kg, 50-100 mL, repeat q4-6 hours if necessary

[Outline]

• Adult Dosing
• Pediatric Dosing

• Short-term treatment of constipation; evacuation of colon for rectal and bowel evaluations

• Hypersensitivity to any of the ingredients of the product
• Heart block
• Appendicitis
• Acute abdomen
• GI obstruction
• abdominal pain
• nausea, vomiting
• Rectal bleading
• Severe renal disease

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined, caution advised
• Renal failure: Avoid use

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Several doses of therapy may develop magnesium poisoning in infants and children. Therefore caution should be exercised
• Avoid use in patients with renal dysfunction. Hypermagnesemia and toxicity may occur due to decreased clearance of magnesium ion
• Events of fluid and electrolyte imbalances, steatorrhea, osteomalacia and vitamin and mineral deficiencies have been reported with chronic use of laxatives leading to laxative dependency
• Rectal bleeding or failure to respond may indicate serious condition requiring further attention
• Significant fluid and electrolyte imbalance may occur due to excessive laxative use

Caution: Use cautiously in

• Renal impairment

Pregnancy Category:NR

Breastfeeding: Safety unknown.

• CV: Palpitations, hypotension
• RESP: Respiratory depression
• CNS: Dizziness, fainting
• GI: Excessive bowel activity, abdominal cramps, diarrhea, perianal irritation, bloating, flatulence
• METABOLIC: Hypermagnesemia
• MISC: Sweating, weakness, fluid and electrolyte imbalance, hypoventilation

• Mineral; attracts and retains water in intestinal lumen, induces urge to defecate by increasing intraluminal pressure
• Absorption: Up to 20%
• Metabolism: None
• Renally excreted
• Half-life: 0.5-5 hrs

US Trade Name(s)

• Only generic available

US Availability

magnesium citrate (generic)

• SOLN: 1.745 g/30 mL

Canadian Trade Name(s)

• N/A

Canadian Availability

UK Trade Name(s)

• Boots Eposm Salt

UK Availability

Boots Eposm Salt

• PWDR for SOLN: 100%

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Gastrointestinal

Laxatives