- The stopper of the vial contains dry natural latex rubber and can cause allergic reactions in latex sensitive individuals
- If patient experiences Arthus-type hypersensitivity reactions following a prior dose of tetanus toxoid, do not give emergency doses of tetanus toxoid containing vaccines more frequently than every 10 years, even if the wound is major or contaminated, as these patients have high serum tetanus antitoxin levels
- If prior vaccine causes Guillain-Barré syndrome within 6 weeks, a decision should be made whether to give any tetanus toxoid-containing vaccine, based on careful consideration of the potential benefits and possible risks. Give other available vaccines if decision is made to withhold tetanus toxoid
- Suspend vaccination with a pertussis-containing vaccine in patients with progressive neurologic disorder, progressive encephalopathy, uncontrolled epilepsy or moderate to severe acute illness, until the condition has stabilized
- Patient’s immunization history should be reviewed for possible vaccine hypersensitivity prior to administering any vaccine. Epinephrine and other appropriate agents and equipments should be made available in case an anaphylactic or acute hypersensitivity reaction occurs
- The expected immune response will not be obtained if vaccine is administered to immunocompromised persons, or persons receiving immunosuppressive therapy
Cautions: Use cautiously in
- Guillian-Barre syndrome within 6 wks of prior tetanus vaccine
- History of reaction to pertussis vaccine
- Progressive or unstable neurologic conditions
- Risk factors for seizures
- Immunosuppressed patients
- Concurrent immunosuppressants
- History of reaction to tetanus toxoid
- Acute illness
Pregnancy Category:C
Breastfeeding: The Centers for Disease Control and Prevention states that vaccines given to a nursing mother do not affect safety of breastfeeding and that breastfeeding is not a contraindication to Tdap vaccine Vaccinate women, who have not received acellular pertussis vaccine with tetanus and reduced diphtheria toxoids (Tdap) previously and have not been vaccinated with Td vaccine within the past 2 years, as soon as feasible in the postpartum period, even if they are breastfeeding. Breastfeeding also reduce infant side effects associated with routine childhood immunization. Vaccinate breastfed infants according to the routine recommended schedules. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 25 March 2011). Manufacturer advises caution.
