Adult Dosing

Eyelash hypotrichosis (Latisse)

• Once nightly, apply 1 gtt to upper eyelid margin at the base of the eyelashes

• Do not apply to lower eyelash eyeline
• Dispose applicator after one use. Use separate applicators for each eyelid

Elevated IOP (Lumigan)

• Instill 1 drop in affected eye(s) in the evening

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Hypotrichosis of the eyelashes (Latisse)
• Elevated intra-ocular pressure in patients with open angle glaucoma or ocular hypertension (Lumigan)

• Hypersensitivity to any of the ingredients of the product
• Hypersensitivity to benzalkonium chloride

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustments

• Prostaglandins analogues, including bimatoprost may cause pigmentation of the iris, periorbital tissue and eyelashes. Growth of eyelashes (reversible) has also occurred. Gradual change in eye color ( i.e., increased amount of brown pigmentation in the iris) may occur
• Potential for hair growth in areas where bimatoprost may come in repeated contact with the skin surface; blot any excess drug from the eyelid margin to avoid it running onto the cheek or other skin areas
• More frequent or concurrent use of bimatoprost and IOP-lowering prostaglandin analogs may decrease the IOP-lowering effect; monitor for changes in intraocular pressure
• Macular edema, including cystoid macular edema has occurred during treatment
• Bacterial keratitis has been reported with multiple-dose containers
• Remove contact lenses prior to and 15 min following administration

Cautions: Use cautiously in

• Aphakia
• Pseudophakia with torn posterior lens capsule
• Risk of macular edema
• Intraocular inflammation (iritis/uveitis)

Pregnancy Category:C

Breastfeeding: Safety unknown, however, due to the short half-life it would not be expected to cause any adverse effects in breastfed infants. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 1 October 2010). Manufacturer advises caution.

• RESP: Common cold, upper respiratory infection
• DERM: Ocular pruritis/burning, conjunctival hyperemia, conjunctivitis, periorbital skin darkening, increases in iris pigmentation, ocular irritation, eyelid erythema, ocular dryness, visual disturbance, foreign body sensation, eye pain, blepharitis, superficial punctuate keratitis, eye discharge, conjunctival edema, abnormal hair growth, iritis

• Prostaglandin analogue; increases aqueous humor outflow through both the trabecular meshwork and uveoscleral routes; decreases intraocular pressure. Mechanism of hair growth is believed to be through increase in the percent of hair in, and the duration of the anagen or growth phase
• Metabolized via oxidation, n-deethylation and glucuronidation
• Renally excreted: 67%, feces: 25% [Based on data from IV route]
• Half-life: 45 mins [Based on data from IV route]

US Trade Name(s)

• Latisse
• Lumigan

US Availability

Latisse

• OPTH SOLN: 0.03%

Lumigan

• OPTH SOLN: 0.03%
• OPTH SOLN: 0.01%

Canadian Trade Name(s)

• Lumigan
• Lumigan RC

Canadian Availability

Lumigan

• OPTH SOLN: 0.03%

Lumigan RC

• OPTH SOLN: 0.01%

UK Trade Name(s)

• Lumigan

UK Availability

Lumigan

• OPTH SOLN: 0.01%
• OPTH SOLN: 0.03%

Australian Trade Name(s)

• Lumigan

Australian Availability

Lumigan

• OPTH SOLN: 0.03%

[Outline]

Ophthalmic

Ophthalmic Glaucoma Agents

Prostaglandin Analogs

Pricing data from www.DrugStore.com in U.S.A.

• Lumigan 0.03 % SOLN [Bottle] (ALLERGAN)
  5 % = $187.99
  10 % = $361.98
• Lumigan 0.01 % SOLN [Bottle] (ALLERGAN)
  2.5 % = $93.99
  7.5 % = $257.96
• Latisse 0.03 % SOLN [Bottle] (ALLERGAN DERMATOLOGICS)
  3 % = $115.99
  9 % = $309.97
• Lumigan 0.03 % SOLN [Bottle] (ALLERGAN)
  7.5 % = $287.98
  22.5 % = $818.99
• Lumigan 0.01 % SOLN [Bottle] (ALLERGAN)
  5 % = $198
  15 % = $574
• Lumigan 0.01 % SOLN [Bottle] (ALLERGAN)
  7.5 % = $297
  22.5 % = $860.99
• Lumigan 0.03 % SOLN [Bottle] (ALLERGAN)
  2.5 % = $99.99
  7.5 % = $280.98

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.