Adult Dosing

Short bowel syndrome

• 30 g PO daily, given in 6 divided doses x 16 wks

• Administer glutamine in conjunction with a recombinant human growth hormone (rhGH)
• Reconstitute each dose with 250 mL (8 oz) of water
• Take the dose with meals or snacks at an interval of 2-3 hrs while awake

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of short bowel syndrome (SBS) in patients receiving specialized nutritional support when used in conjunction with a recombinant human growth hormone

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined; periodically monitor renal function

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined; periodically monitor hepatic function

See Supplemental Patient Information

• Glutamine is metabolized to glutamate and ammonia, which may increase in patients with hepatic impairment. Hence, monitor hepatic and renal functions periodically during therapy, particularly in patients with hepatic or renal impairment

Cautions: Use cautiously in

• Renal impairment
• Hepatic impairment

Supplemental Patient Information

• Advise patients to delay a dose for up to 2 hrs in the event of a transient intolerance to oral intake

Pregnancy Category:C

Breastfeeding: Safety unknown. Manufacturer advises caution.

• CNS: Dizziness, headache
• PSYCHIATRY: Depression, insomnia
• NEURO: Hypoasthesia
• GI: Enlarged abdomen, flatulence, abdominal pain, nausea, vomiting, constipation, tenesmus, hemorrhoids, dry mouth, pancreatitis, Crohn's disease aggravated, gastric ulcer, GI fistula, abnormal hepatic function
• MUSC: Arthralgia, myalgia, back pain
• RESP: Rhinitis, laryngitis, pharyngitis
• CV: Chest pain, vascular disorder
• DERM: Rash, pruritus, increased sweating, nail disorder
• METABOLIC: Dehydration, thirst
• EENT: Ear or hearing disorder
• GU: Pyelonephritis, renal calculus
• LOCAL: Injection site reaction
• REPRODUCTION: Breast pain (females), vaginal fungal infection
• MISC: Peripheral edema, facial edema, pain, fever, flu-like symptoms, malaise, generalized edema, allergic reaction, chills, bacterial infection, vial infection, moniliasis, sepsis, fatigue

• Amino acid supplement; regulates GI cell growth, function, and regeneration. In catabolic disease states, glutamine concentrations reduce and metabolism of tissue glutamine increases, making it a conditionally essential amino acid
• Metabolized by liver
• Renally excreted
• Half-life: 1 hr (based on IV administration)

US Trade Name(s)

• NutreStore

US Availability

NutreStore

• PWDR for SOLN: 5 g/pckt

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Gastrointestinal

GI Agents; Miscellaneous