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Interacting Drugs

OBJECT DRUGS

PRECIPITANT DRUGS

Enzyme Inducers:


Comment:

Bedaquiline is metabolized by CYP3A4, and enzyme inducers may substantially reduce serum bedaquiline concentrations. In one study, 3 weeks of rifampin therapy reduced bedaquiline AUC by about 50%. The product information for bedaquiline states that enzyme inducers should not be administered with bedaquiline. Although nevirapine (Viramune) is a CYP3A4 inducer, the manufacturer reports that 4 weeks of nevirapine 400 mg daily did not have a clinically relevant effect on bedaquiline exposure.


Class 2: Use only if Benefit Felt to Outweigh Risk