OBJECT DRUGS

Cholinesterase Inhibitors:

• Donepezil (Aricept, etc.)
• Galantamine (Razadyne, etc.)
• Rivastigmine (Exelon)

PRECIPITANT DRUGS

Bradycardic Drugs:

• Ceritinib (Zykadia)
• Digoxin (Lanoxin, etc.)

Comment:

Cholinesterase inhibitors increase vagal tone, which tends to slow the heart rate. When they are given with other drugs that slow heart rate such as ceritinib or digoxin, excessive bradycardia can result. In some cases the combination of cholinesterase inhibitors and bradycardic drugs has been associated with life-threatening reactions, with severe bradycardia, cardiac arrhythmias, and even cardiac arrest. More study is needed to establish the importance of these interactions, but the potential severity of the reactions dictates that the combinations should be used only with close monitoring.

Class 2: Use Only if Benefit Felt to Outweigh Risk

• Use Alternative: If appropriate for the patient, consider using an alternative to the cholinesterase inhibitor or the bradycardic drug.
• Circumvent/Minimize::In some cases of excessive bradycardia due to cholinesterase inhibitor drug interactions, a cardiac pacemaker has been inserted and the drugs continued.
• Monitor:If the combination is used, monitor the heart rate for excessive slowing, and be alert for other adverse effects such as lightheadedness, dizziness, hypotension and fainting.