Adult Dosing

Seasonal allergic rhinitis

• Astepro: 1-2 sprays/nostril 0.1% or 0.15% bid; alt: 2 sprays/nostril 0.15% qd
• Astelin: 1-2 sprays/nostril bid

Perennial allergic rhinitis

• Astepro: 2 sprays/nostril 0.15% bid

Vasomotor rhinitis

• Astelin: 2 sprays/nostril bid

Pediatric Dosing

Seasonal allergic rhinitis

Children 12 yrs

• Astepro: 1-2 sprays/nostril 0.1% or 0.15% bid; alt: 2 sprays/nostril 0.15% qd
• Astelin: 1-2 sprays/nostril bid

Children 5-11 yrs

• Astelin: 1 spray/nostril bid

Perennial allergic rhinitis

Children 12 yrs

• Astepro: 2 sprays/nostril 0.15% bid

Vasomotor rhinitis

Children 12 yrs

• Astelin: 2 sprays/nostril bid

[Outline]

• Adult Dosing
• Pediatric Dosing

• Relief of symptoms of seasonal and perennial allergic rhinitis in patients 12 years (Astepro)
• Treatment of seasonal allergic rhinitis symptoms such as rhinorrhea, sneezing, and nasal pruritus in adults and children 5 yrs (Astelin)
• Treatment of symptoms of vasomotor rhinitis including rhinorrhea, nasal congestion, and postnasal drip in adults and children 12 yrs (Astelin)

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• Somnolence has been reported in patients taking azelastine nasal spray; advise patients not to engage in hazardous tasks requiring mental alertness and motor coordination such as operating machinery or driving a motor vehicle
• Avoid concomitant use of azelastine with alcohol or other CNS depressants because additional impairment of CNS performance may occur

Supplemental Patient Information

• Advise patients to refrain from performing hazardous tasks such as driving a vehicle or operating heavy machinery after receiving azelastine nasal spay
• Instruct patients to prime the pump until a fine mist appears before initial use and when 3 or more days have elapsed since the last use
• Advise patients to avoid spraying into their eyes or mouth

Astelin, Astepro interacts with :

	Aricept
	Aricept ODT
	Donepezil
	Exelon
	Galantamine
	Razadyne
	Razadyne ER
	Rivastigmine

Pregnancy Category:C

Breastfeeding: Limited information indicates that small occasional doses of azelastine would not be expected to cause any adverse effects in breastfed infants. Larger doses or more prolonged use of the nasal spray may cause drowsiness in the infants or decrease the milk supply, especially in combination with pseudoephedrine. Non-sedating antihistamines are preferred alternatives. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 21 October 2010). As per the manufacturer's data, this drug should be used with caution in nursing women.

• EENT: Epistaxis, nasal burning, nasopharyngitis, rhinitis, sinusitis, nasal mucosal ulceration, paroxysmal sneezing, nasal discomfort, conjunctivitis, pharyngitis
• RESP: Cough, asthma
• CNS: Headache, fatigue, somnolence, dizziness, dysesthesia
• GI: Bitter taste, dry mouth, nausea
• METABOLIC: Weight gain
• MUSC: Myalgia
• HYPERSENSITIVITY: Anaphylactoid reactions

• Antihistamine; antagonizes central and peripheral H1 receptors and thereby reduces the intensity of allergic reactions and tissue injury response involving histamine release resulting in decreased sneezing, nasal rhinitis, pruritus, and post-nasal drip
• Bioavailability is 40% after nasal administration
• Metabolized in the liver by CYP450 into its active metabolite, desmethylazelastine
• Excreted in feces 75% (<10% unchanged)
• Half-life:
• Astepro 0.1%: 22 hrs (azelastine); 52 hrs (desmethylazelastine)
• Astepro 0.15%: 25 hrs (azelastine); 57 hrs (desmethylazelastine)
• Astelin: 22 hrs (azelastine); 54 hrs (desmethylazelastine)

US Trade Name(s)

• Astelin
• Astepro

US Availability

azelastine (generic)

• Nasal spray: 0.1% (137 mcg/metered spray)
• Nasal spray: 0.1876 mg/spray

Astelin

• Nasal spray: 137 mcg/metered spray

Astepro

• Nasal spray: 0.1% (137 mcg/metered spray)
• Nasal spray: 0.15% (205.5 mcg/metered spray)

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• Rhinolast

UK Availability

Rhinolast

• Nasal spray: 140 mcg/metered spray

Australian Trade Name(s)

• Azep

Australian Availability

Azep

• Nasal spray: 0.1% (140 mcg/metered spray)

[Outline]

ENT

Nasal Preparations

Antihistamines & Decongestants

Allergy & Immunology

Nasal Preparations

Antihistamines & Decongestants

Pricing data from www.DrugStore.com in U.S.A.

• Astepro 0.15 % SOLN [Spray Btl] (MEDA PHARMACEUTICALS)
  30 % = $116
  90 % = $319.96
• Azelastine HCl 137 MCG/SPRAY SOLN [Bottle] (APOTEX)
  30 spray = $95.99
  90 spray = $265.96
• Astelin 137 MCG/SPRAY SOLN [Bottle] (MEDA PHARMACEUTICALS)
  30 spray = $134
  90 spray = $378.96

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.