Adult Dosing
Superficial bacterial infection/ minor skin injuries
- Apply to affected areas qd-tid (for short term use only)
- Note: After application cover the affected area with sterile bandage
Pediatric Dosing
Superficial bacterial infection/ minor skin injuries
- >2 yrs: Apply to affected areas qd-tid (for short term use only)
[Outline]
- Hypersensitivity reactions like contact dermatitis, burning, erythema, rash, and urticaria occur with neomycin topical application. Discontinue the drug if such reaction occurs
- May cause sensitization and cross-sensitivity with other aminoglycoside antibacterials
- Topical neomycin treatment for skin ulcers, granulating wounds, burns, or extensive areas of denuded skin, irrigation of wounds or surgical sites causes ototoxicity, nephrotoxicity, and neuromuscular blockade, use cautiously in such conditions
- Diapers act as an occlusive dressing, therefore, topical neomycin applied to large areas of abraded skin in infants with diaper rash may result in substantial absorption
- Concomitant use of corticosteroids with topical neomycin masks the clinical signs of bacterial, fungal, or viral infections, or may suppress hypersensitivity reactions
- Discontinue the drug and start appropriate therapy if there is overgrowth of non susceptible organisms like fungi
Cautions: Use cautiously in
- Extensive burns
- Trophic ulceration
- Extensive dermatologic conditions where rapid absorption is possible
- Large surface areas (systemic toxicity possible)
- >20% BSA burns (use only once)
Pregnancy Category:C
Breastfeeding: Safety unknown; Topical neomycin is excreted in very low levels in breastmilk and presents negligible risk to the infant; however topical application to the nipple may increase the risk of diarrhea in the infant. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 28 December 2010).
