Adult Dosing

Minor bleeding; hemostatic aid

• Apply on the surface of bleeding tissue only; apply directly to bleeding site or in conjunction with absorbable gelatin sponge
• Dosage varies depending on the size and number of bleeding sites and the method of application
• Reconstitute the lyophilized powder using supplied diluent in less than 1 minute at room temperature

Pediatric Dosing

• Safety and effectiveness in pediatric patients have not been established

[Outline]

• Adult Dosing
• Pediatric Dosing

• Indicated as an aid to hemostasis when oozing blood and minor bleeding from capillaries and small venules is accessible and when standard surgical techniques are ineffective or impractical in controlling bleeding

• Hypersensitivity to any of the ingredients of the product
• Injection directly into the circulatory system
• Treatment of massive or brisk arterial bleeding
• Hypersensitivity to hamster proteins

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustment

Hepatic Dose Adjustment

• Hepatic impairment: No dose adjustment

• In patients with known hypersensitivity to snake proteins, thrombin may cause an allergic reaction
• Potential risk of thrombosis if absorbed systemically

Caution: Use cautiously in

• Elderly patients

Pregnancy Category:C

Breastfeeding: Safety unknown.

• CV: Atrial fibrillation
• GI: Nausea, vomiting
• HEMA: Bleeding, thromboembolism
• MISC: Incision site complication, procedural pain, hypersensitivity, other infection, antibody formation, post-operative wound infection

• Hematologic agent; highly specific human serine protease that promotes hemostasis and acts locally when applied to a bleeding site. Also, activates platelets and catalyzes the conversion of fibrinogen to fibrin, required for blood clot formation
• Metabolized by liver
• Half-life: Unknown

US Trade Name(s)

• Recothrom

US Availability

Recothrom

• PWDR for SOLN: 5000-unit vial (with 5-mL diluent)
• PWDR for SOLN: 20,000-unit vial (with 20-mL diluent)
• PWDR for SOLN: 20,000-unit kit (with a spray applicator kit)

Canadian Trade Name(s)

• Recothrom

Canadian Availability

Recothrom

• PWDR for SOLN: 6000-unit vial (with 5-mL diluent)
• PWDR for SOLN: 24,000-unit vial (with 20-mL diluent)

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Hematology/Oncology

Hemostatic Agent

Coagulation Modifiers

Cardiovascular

Hemostatic Agent

Coagulation Modifiers