Adult Dosing

Abdominal Distention

• Initial dose 5 units (0.25 mL) IM; increase to 10 units (0.5 mL) PRN
• Repeat the dose at 3-4 hrs intervals if necessary

Abdominal Roentgenography

• 2 injections of 10 units (0.5 mL) IV x 2 minutes and 30 minutes before films are exposed

Diabetes Insipidus

• 5-10 units (0.25-0.5 mL) SC/IM bid-tid

Pediatric Dosing

Abdominal Distention

• Children may be given proportionately reduced doses

Abdominal Roentgenography

• Children may be given proportionately reduced doses

Diabetes Insipidus

• Children may be given proportionately reduced doses

[Outline]

• Adult Dosing
• Pediatric Dosing

• Prevention and treatment of postoperative abdominal distention, facilitation of abdominal roentgenography, and diabetes insipidus

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: No dose adjustments

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Avoid vasopressin in patients with vascular disease, especially disease of the coronary arteries; in such patients, small doses may precipitate anginal pain and with larger doses, the possibility of myocardial infarction
• Therapy may produce water intoxication; signs of drowsiness, listlessness, and headaches should be recognized to prevent terminal coma and convulsions
• Caution should be exercised when therapy is used in presence of epilepsy, migraine, asthma, heart failure, or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system
• Electrocardiograms (ECG) and fluid and electrolyte status evaluation is recommended at periodic intervals during therapy

Caution: Use cautiously in

• CHF
• CAD
• Asthma
• Migraine
• Elderly patients

Pregnancy Category:C

Breastfeeding: Safety unknown. Manufacturer advises caution in nursing women.

• CV: Cardiac arrest, circumoral pallor, arrhythmia, decreased cardiac output, angina, myocardial ischemia, peripheral vasoconstriction, angina
• CNS: Tremor, pounding in head
• GI: Abdominal cramps, nausea, vomiting, passage of gas
• DERM: Sweating, urticaria, cutaneous gangrene
• EENT: Vertigo
• RESP: Bronchial constriction
• HYPERSENSITIVITY: Anaphylaxis

• Antidiuretic hormone; increases reabsorption of water by the renal tubules; stimulates contraction of smooth muscle causing vasoconstriction
• Rapidly metabolized by liver and kidney
• Excreted in urine (5%) after 4 hours
• Half-life: 10-20 mins

US Trade Name(s)

• Only generic available

US Availability

vasopressin (generic)

• INJ: 20 units/mL (1 mL vial)

Canadian Trade Name(s)

• Only generic available

Canadian Availability

vasopressin (generic)

• INJ: 20 units/mL (1 mL vial)

UK Trade Name(s)

• Only generic available

UK Availability

vasopressin (generic)

• INJ: 20 units/mL (1 mL vial)

Australian Trade Name(s)

• Pitressin

Australian Availability

Pitressin

• INJ: 20 units/mL

[Outline]

Endocrine/Metabolic

Antidiuretic Agent

Vasopressin Analogue

Pricing data from www.DrugStore.com in U.S.A.

• Vasopressin 20 UNIT/ML SOLN [Vial] (AMERICAN REGENT)
  1 ml = $13.99
  3 ml = $19.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.