Adult Dosing

Allergic conjunctivitis

• Instill 1 gtt in each affected eye(s) bid for up to 8 wks

Pediatric Dosing

Allergic conjunctivitis

• Child(>3 yrs): Instill 1 gtt in each affected eye(s) bid for up to 8 wks

[Outline]

• Adult Dosing
• Pediatric Dosing

• Allergic conjunctivitis

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• For ocular use only; not for injection or oral use
• Assess ophthalmic symptoms before and periodically throughout therapy
• Safety and efficacy in children younger than 3 yrs of age have not been established

Supplemental Patient Information

• To prevent contaminating the dropper tip and solution, do not touch any surface, the eyelids, or surrounding areas with the dropper tip
• Advise patients to avoid using contact lenses during therapy

Optivar interacts with :

	Aricept
	Aricept ODT
	Donepezil
	Exelon
	Galantamine
	Razadyne
	Razadyne ER
	Rivastigmine

Pregnancy Category:C

Breastfeeding: It is not known if azelastine is excreted in breast milk; however, due to minimal systemic absorption, it would not be expected to adversely affect the breastfed infant. This information is based upon lactmed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 21 October 2010). Manufacturer advises caution.

• EENT: Ocular burning/stinging, temporary blurring, conjunctivitis, ocular pain, pharyngitis, rhinitis
• CNS: Headache
• RESP: Asthma, dyspnea, epistaxis
• DERM: Pruritis
• MISC: Bitter taste in mouth, fatigue, influenza-like symptoms

• Antihistamine; antagonizes central and peripheral H1 receptors; reduce the intensity of allergic reactions and tissue injury response involving histamine release; decreases chemotaxis and activation of eosinophils
• Minimal systemic availability after ophthalmic application
• Oxidatively metabolized by liver to principal metabolite, N-desmethylazelastine, by cytochrome P450
• Excreted in feces: 75% (<10% unchanged)
• Half-life: 22 hrs (azelastine); 54 hrs (N-desmethylazelastine) [Note: Based on oral and IV administration]

US Trade Name(s)

• Optivar

US Availability

azelastine (generic)

• OPTH SOLN: 0.05%

Optivar

• OPTH SOLN: 0.05%

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• Optilast

UK Availability

Optilast

• OPTH SOLN: 0.05%

Australian Trade Name(s)

• Eyezep

Australian Availability

Eyezep

• OPTH SOLN: 0.05%

[Outline]

Ophthalmic

Antihistamine

Ophthalmic

Ophthalmic Antihistamines & Decongestants

Allergy & Immunology

Ophthalmic Antihistamines & Decongestants

Pricing data from www.DrugStore.com in U.S.A.

• Optivar 0.05 % SOLN [Bottle] (MEDA PHARMACEUTICALS)
  6 % = $121.79
  18 % = $352.74

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.