Adult Dosing
Palliative treatment of advanced prostate cancer
leuprolide
Eligard
- 7.5 mg SC q month; 22.5 mg SC q3 months; 30 mg SC q4 months; 45 mg SC q6 months
Lupron Depot
Lupron Depot-3
Lupron Depot-4
Lupron Depot-6
Endometriosis
Lupron Depot
- 3.75 mg IM once monthly; usual duration <6 months
Lupron Depot-3
- 11.25 mg IM q3 months; usual duration <6 months
Uterine fibroids
Lupron Depot
- 3.75 mg IM once monthly; usual duration <3 months
Lupron Depot-3
- 11.25 mg IM x 1
- Note : Use with iron supplementation
Polycystic Ovary Syndrome (PCOS) [Non-FDA Approved]
- 3.75 mg IM qmonth x 6 months
- Alt: 11.25 mg IM q3 months x 2 doses; duration: 6 months
Pediatric Dosing
Management of central precocious puberty
leuprolide (generic)
- Dose range: 35-50 mcg/kg SC qd
- Alt: 0.15-0.3 mg/kg IM q4 wks
Lupron
- Start 50 mcg/kg SC qd; may increase 10 mcg/kg/day until total downregulation
Lupron Depot-Ped
- 0-25 kg: Start 7.5 mg IM q4 wks, may increase 3.75 mg q4 wks until total downregulation
- 26-37.5 kg: Start 11.25 mg IM q4 wks, may increase 3.75 mg q4 wks until total downregulation
- >37.5 kg: Start 15 mg IM q4 wks, may increase 3.75 mg q4 wks until total downregulation
Lupron Depot-Ped 3 Month
- Start 11.25 mg or 30 mg IM q12 wks
- Note : Discontinuation of treatment should be considered before age 11 for females and age 12 for males
[Outline]
- Therapy may cause increases in serum levels of testosterone, temporary increase in bone pain, ureteral obstruction and spinal cord compression, paralysis with or without fatal complications
- Periodically monitor serum testosterone and prostate specific antigen (PSA) levels during therapy
- Response to the drug should be monitored 1-2 months after the start of therapy with a GnRH stimulation test and sex steroid levels
- Events of hyperglycemia and an increased risk of developing diabetes have also been reported with the therapy. Monitor blood glucose and/or glycosylated hemoglobin (HbA1c) periodically in patients receiving a GnRH agonist and manage with current practice for treatment of hyperglycemia or diabetes
- Measurement of bone age for advancement should be done every 6-12 months
- Leuprolide may cause fetal harm when administered to a pregnant woman, hence it is contraindicated in women who are, or may become pregnant while receiving the drug
- Myocardial infarction, sudden cardiac death and stroke have been reported in association with use of GnRH agonists in men
- Carefully monitor and appropriately manage signs and symptoms suggestive of development of cardiovascular disease
- During the first few weeks of therapy, closely monitor patients with metastatic vertebral lesions and/or with urinary tract obstruction
- Convulsions reported in postmarketing studies among patients with a history of seizures, epilepsy, cerebrovascular disorders, CNS anomalies or tumors, and those taking concomitant medications that have been associated with convulsions such as bupropion and SSRIs
Cautions: Use cautiously in
- Hypersensitivity to benzyl alcohol
- Psychiatric disorder
- Urinary tract obstruction
- Vertebral metastases
- Cardiovascular disease
- Diabetes
- Depression
- Vertebral metastases (prostate CA use)
- Hematuria
- Osteoporosis risk
Pregnancy Category:X
Breastfeeding: Safety unknown, use not recommended.
Pricing data from www.DrugStore.com in U.S.A.
- Lupron Depot 11.25 MG KIT [Box] (ABBOTT)
1 mg = $2208.91
3 mg = $6527.96 - Lupron Depot 7.5 MG KIT [Box] (ABBOTT)
1 mg = $927
3 mg = $2711.02 - Leuprolide Acetate 1 MG/0.2ML KIT [Box] (SUN PHARMACEUTICAL)
1 0.2ml = $350.01
3 0.2ml = $990.03 - Lupron Depot 30 MG KIT [Box] (ABBOTT)
1 mg = $3394.87
3 mg = $10115.5 - Lupron Depot-Ped 7.5 MG KIT [Box] (ABBOTT)
1 mg = $960.04
3 mg = $2819.82 - Lupron Depot 22.5 MG KIT [Box] (ABBOTT)
1 mg = $2756.94
3 mg = $8206.7 - Lupron Depot 3.75 MG KIT [Box] (ABBOTT)
1 mg = $720.98
3 mg = $2134.92
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
