Adult Dosing
Treatment of peptic ulcer
- 15 mg PO tid; 30 minutes before each meal and 30 mg PO qhs
- Max: 75 mg/day
- Patients with mild manifestations, geriatric patients, and those of small stature: 7.5 mg PO tid; 30 minutes before each meal
Pediatric Dosing
- Safety and effectiveness in pediatric patients have not been established
See Supplemental Patient Information
- In high environmental temperature, propantheline can cause heat prostration (fever and heat stroke due to decreased sweating)
- Patient should be advised not to operate motor vehicle or other machinery or performing hazardous work or activities requiring mental alertness as drug may cause drowsiness or blurred vision
- Overdosage can cause neuromuscular blockade leading to muscular weakness and possible paralysis
- Concurrent use of the drug with slow-dissolving tablets of digoxin may cause increased serum digoxin levels; avoid by using rapidly dissolvable digoxin tablets
- Concurrent use of the drug with belladonna alkaloids, synthetic or semisynthetic anticholinergic agents, narcotic analgesics such as meperidine, type 1 antiarrhythmic drugs , antihistamines, phenothiazines, tricyclic antidepressants, or other psychoactive drugs, can result in excessive cholinergic blockade
- Concurrent use of the drug with corticosteroids may result in increased intraocular pressure
Cautions: Use cautiously in
- Renal and hepatic impairment
- CAD
- Elderly patients
- Autonomic neuropathy
- Congestive heart failure
- Cardiac tachyarrhythmias
- Hyperthyroidism
- Hiatal hernia
- Hypertension
- Ulcerative colitis
Supplemental Patient Information
- Patients are advised not to perform hazardous work or activities requiring mental alertness and should not operate motor vehicle or other machinery as the drug may cause drowsiness or blurred vision
Pregnancy Category:C
Breastfeeding: Safety unknown; no information is available on the use of propantheline during breastfeeding. As propantheline is a quaternary ammonium compound, it is not likely to be absorbed and reach the bloodstream of the infant. Long-term use of propantheline might reduce milk production or milk letdown; observe for signs of decreased lactation-insatiety, poor weight gain. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 24 Nov 2010). Manufacturer advises caution.
