rifaximin

Adult Dosing

Travelers’ diarrhea

200 mg PO tid x 3 days

Hepatic encephalopathy

550 mg PO bid

Pediatric Dosing

Travelers’ diarrhea

Child 12 yrs: 200 mg PO tid x 3 days
Note : Safety and effectiveness in pediatric patients <12 yrs have not been established

Hepatic encephalopathy

Safety and effectiveness in pediatric patients <18 yrs have not been established

Indications ⬆ ⬇

Travelers’ diarrhea caused by Escherichia coli
Hepatic encephalopathy

Contraindications ⬆ ⬇

Hypersensitivity to any ingredient of the product
Diarrhea caused by pathogens other than Escherichia coli or complicated by fever or blood in the stool

Black Box Warnings ⬆ ⬇

Dosing Adjustment ⬆ ⬇

Renal Dose Adjustment

Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

Mild-moderate Hepatic impairment: No dose adjustments
Severe hepatic impairment (Child-Pugh C): Use cautiously, dose adjustments not defined

Warnings/Precautions ⬆ ⬇

See Supplemental Patient Information

Should be discontinued if diarrhea symptoms get worse or persist more than 24-48 hours and alternative antibiotic therapy should be considered
Not effective in travelers’ diarrhea caused by Campylobacter jejuni, Shigella spp., or Salmonella spp
Clostridium difficile-associated diarrhea (CDAD) ranging in severity from mild diarrhea to life-threatening colitis may occur
Maintain appropriate fluid and electrolyte levels, protein supplementation, along with antibiotics for C. difficile and also evaluate surgical intervention as needed
To be prescribe in proven or strongly suspected bacterial infection only or else it may increases the risk of the development of drug-resistant bacteria

Caution: Use cautiously in

Severe hepatic impairment (Child-Pugh C)

Supplemental Patient Information

Patients should discontinue the drug if diarrhea persists more than 24-48 hours and should seek medical advice if there is fever and/or blood in the stool

Pregnancy/Breast Feeding ⬆ ⬇

Pregnancy Category:C

Breastfeeding: Safety Unknown; because of the potential for possible serious adverse reactions in nursing infants manufacturer recommends discontinuation of breastfeeding, or discontinuation of drug (taking into account the importance of the drug to the mother).

Adverse Reactions ⬆ ⬇

GI: CDAD, flatulence, Abdominal pain, abdominal distention, ascites, rectal tenesmus, defecation urgency, nausea, constipation, vomiting
CNS: Headache, dizziness, depression, insomnia
MUSC: Muscle spasms, arthralgia, back pain
RESP: Cough, dyspnea
HEMA: Anemia
EENT: Nasopharyngitis
HYPERSENSITIVITY: Exfoliating dermatitis, pruritus, rash, angioneurotic edema, urticaria, anaphylaxis
MISC: Pyrexia, peripheral edema, fatigue, superinfection

Clinical Pharmacology ⬆ ⬇

Non-aminoglycoside antibacterial; inhibits bacterial RNA synthesis by binding to the beta-subunit of bacterial DNA-dependent RNA polymerase
Not metabolized significantly; CYP450: unknown; minimal/no systemic absorption
Renally excreted: 0.32%; feces: 97% (primarily unchanged)
Half-life: 6 hrs

Brands and Availability ⬆ ⬇

US Trade Name(s)

Xifaxan

US Availability

Xifaxan

TABS: 200 mg
TABS: 550 mg

Canadian Trade Name(s)

Canadian Availability

UK Trade Name(s)

UK Availability

Australian Trade Name(s)

Australian Availability

Classification ⬆ ⬇

Antimicrobials

Antibiotics
Miscellaneous Agents

Infectious Disease

Antibiotics
Miscellaneous Agents

Pricing ⬆ ⬇

Pricing data from www.DrugStore.com in U.S.A.

Xifaxan 550 MG TABS [Bottle] (SALIX PHARMACEUTICALS)
INC. mg = $60
mg = $180
Xifaxan 200 MG TABS [Bottle] (SALIX PHARMACEUTICALS)
INC. mg = $30
mg = $90

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

Pill ⬆

Drug Name: XIFAXAN 200 MG Oral Tablet

Ingredient(s): Rifaximin

Imprint: Sx

Color(s): Pink

Shape: Round

Size (mm): 10.00

Score: 1

Inactive Ingredient(s): colloidal silicon dioxide / edetate disodium / glyceryl distearate / hypromellose / cellulose, microcrystalline / propylene glycol / ferric oxide / sodium starch glycolate type a potato / talc / titanium dioxide

Drug Label Author:
Salix Pharmaceuticals, Inc

DEA Schedule:
Non-Scheduled

Drug Name: XIFAXAN 550 MG Oral Tablet