Adult Dosing
Bacterial infections
- 1-2 gm/day PO div bid-qid
- Info: Give at least 1h before or 2h after meals
acne vulgaris[125-250 mg PO qid]
- Alt: 250-500 mg PO bid
- Info: Give at least 1h before or 2h after meals
Chlamydia infections
- 500 mg PO qid x7-10 days
- Info: Give at least 1h before or 2h after meals
H. pylori infections
- 500 mg PO qid x10-14 days in combination with H.pylori regimen
Malaria [Non FDA-Approved]
COPD exacerbation[Non-FDA Approved]
Pediatric Dosing
Bacterial infections
- >8 yrs: 25-50 mg/kg/day PO divided q6h. Max: 3 g/day
- Info: Give at least 1h before or 2h after meals
Acne
- 250-500 mg PO q6-12h for 1-2 weeks, then 250-500 mg PO daily
- Info: Give at least 1h before or 2h after meals
Chlamydial infections
- >8 yrs: 25-50 mg/kg/day PO divided q6h x 7 days. Max: 3 g/day
- Info: Give at least 1h before or 2h after meals
Malaria [Non FDA-Approved]
- 25 mg/kg/daily PO divided 4 times for 7 days
-
[Outline]
Renal Dose Adjustment (Based on CrCl)
- >50 mL/min: q8-12 hrs
- 10-50 mL/min: q12-24 hrs
- <10 mL/min: q24 hrs
Hepatic dose adjustment
- Hepatic impairment: Dose adjustments not defined, caution advised
See Supplemental Patient Information
- It is not the drug of choice for any type of stapylococcal infections
- Culture and susceptibility tests should be performed to determine the causative organism and its susceptibility to the drug
- Tetracyclines can cause fetal harm when administered to a pregnant woman. If the patient becomes pregnant during therapy, apprise the patient of the potential hazard to the fetus
- Use of tetracyclines during tooth development (last half of pregnancy, infancy and childhood till the age of 8 yrs) may cause permanent discoloration of teeth. Hence it should not be used in this age group
- Use of this drug may result in overgrowth of nonsusceptible organisms including fungi. Discontinue therapy institute appropriate therapy if new infections develop
- Tetracyclines can cause photosensitivity and pseudotumor cerebri (avoid use with isotretinoin)
- Excessive accumulation may occur in patients with renal function impairment, dosage reduction may be required
- Measure BUN, serum creatinine at baseline, then periodically if prolonged therapy
- Monitor CBC, LFTs if prolonged therapy
- Suspend therapy if superinfection occurs and institute appropriate therapy
- Incidences of bulging fontanels in infants and benign intracranial hypertension in adults have been reported in individuals receiving tetracyclines
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- SLE
- Geriatric population
- Pediatric population <8 yrs
Supplemental Patient Information
- Take at least 1 hour before or 2 hours after meals
Pregnancy Category:D
Breastfeeding: Unsafe. Most sources consider that tetracyclines are contraindicated during breastfeeding due to possible staining of infants' dental enamel or bone deposition. However short term use of tetracyclines would not adversely affect the breast fed infant. Avoid prolonged or repeated courses of therapy during nursing. Monitor the infant for adverse events such as rash, diarrhea or candidiasis. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 17 March 2011). Due to the potential for serious adverse reactions in nursing infants, manufacturer recommends discontinuation of nursing or discontinuation of drug, taking into account the importance of the drug to the mother.
Pricing data from www.DrugStore.com in U.S.A.
- Tetracycline HCl 500 MG CAPS [Bottle] (WATSON LABS)
100 mg = $19.99
200 mg = $28.97
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.
