Adult Dosing
Inflammatory and pruritic dermatose
- Apply thin layer bid x 2 wks
- Max: 50 g/wk
Scalp dermatose
- Apply thin layer of foam/solution bid x 2 wks
- Max: 50 g/wk
Moderate to severe plaque-type psoriasis
- Apply thin layer of foam/lotion/spray/cream emollient bid x 4 wks
- Max: 50 g/wk
Scalp psoriasis
- Apply shampoo on dry scalp qd x 4 wks
- Leave shampoo for 15 mins then rinse thoroughly
- Max: 50 g/wk
Notes:- Do not apply on face, axillae, or groin
- Do not put bandage or occlusive dressing on the treated area
- Do not use in patients with primary infections of the scalp
Pediatric Dosing
- Safety and efficacy of clobetasol cream, ointment, foam, gel, or solution have not been established in children <12 yrs of age
- Safety and efficacy of clobetasol lotion and shampoo have not been established in pediatric patients (Clobex)
Inflammatory and pruritic dermatoses >12 yrs (Embeline, Olux, Temovate)
- Apply thin layer bid x 2 wks
- Max: 50 g/wk
Corticosteroid-responsive dermatoses of scalp >12 yrs (Embeline, Olux, Temovate)
- Apply thin layer bid x 2 wks
- Max: 50 g/wk
Moderate to severe plaque-type psoriasis (Embeline, Olux, Temovate)
- Apply thin layer bid x 2 wks
- Max: 50 g/wk
Notes:- Do not apply on face, axillae, or groin
- Do not put bandage or occlusive dressing on the treated area
- Do not use in patients with primary infections of the scalp
[Outline]
- Reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome, hyperglycemia and glucosuria have occurred due to systemic absorption of topical corticosteroid
- Application of the more potent steroids, large surface areas, prolonged use and occlusive dressing add on to the systemic absorption
- Monitor the patient periodically for HPA axis suppression, discontinue or reduce the frequency of application, or substitute with a less potent steroid if HPA- axis suppression noted
- Discontinue the drug is any local irritation develops. In case of any dermatological infection, appropriate antifungal or antibacterial agent should be used
- Pediatric patients are more susceptible to systemic toxicity (HPA axis suppression, Cushing's syndrome and intracranial hypertension) as proportionally larger amounts of topical corticosteroids is absorbed
- Limit the use of topical corticosteroid in pediatric patients to the least amount compatible with an effective therapeutic regimen. Long term corticosteroid therapy in pediatric patients may interfere with their growth and development
- Do not use for the treatment of rosacea or perioral dermatitis, and avoid use on the face, groin, or axillae as they are more prone to atrophic changes than other areas of the body
Cautions: Use cautiously in
- Pediatric patients
- Skin infection
Pregnancy Category:C
Breastfeeding: No studies conducted during breastfeeding; short-term application of topical corticosteroids is not expected to pose a risk to the breastfed infant by passage into breastmilk. Use of the least potent drug on the smallest area of skin of mother is recommended. Ensure that the infant's skin does not come into direct contact with the areas treated with this drug. Use of lower potency corticosteroids, water-miscible cream products on the nipple or areola is recommended. Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is applied to the nipple or areola. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 22 December 2010). However manufacturer advises caution while administrating nursing mothers.
US Trade Name(s)
- Clobex
- Cormax
- Embeline
- Embeline E
- Olux
- Olux E
- Temovate
- Temovate E
US Availability
clobetasol propionate (generic)
- CRE: 0.05%
- OINT: 0.05%
- GEL: 0.05%
- SOLN: 0.05%
- FOAM: 0.05%
- LOTN: 0.05%
- SHAM: 0.05%
clobetasol propionate Emollient(generic)
Clobex
- LOTN: 0.05%
- SHAM: 0.05%
- SPRAY: 0.05%
Cormax
Embeline
- OINT: 0.05%
- GEL: 0.05%
- SOLN: 0.05%
Embeline E
Olux
Olux E
Temovate
- CRE: 0.05%
- OINT: 0.05%
- GEL: 0.05%
- SOLN: 0.05%
Temovate E
Canadian Trade Name(s)
Canadian Availability
clobetasol propionate (generic)
- CRE: 0.05%
- OINT: 0.05%
- SOLN: 0.05%
- LOTN: 0.05%
Clobex
- LOTN: 0.05%
- SHAM: 0.05%
- SPRAY: 0.05%
Dermovate
- CRE: 0.05%
- OINT: 0.05%
- SOLN: 0.05%
UK Trade Name(s)
UK Availability
Clarelux
Dermovate
- CRE: 0.05%
- OINT: 0.05%
- SOLN: 0.05%
Etrivex:
Australian Trade Name(s)
Australian Availability
[Outline]
Pricing data from www.DrugStore.com in U.S.A.
- Temovate 0.05 % GEL [Tube] (PHARMADERM)
15 % = $39.99
45 % = $109.97 - Clobetasol Propionate 0.05 % SOLN [Bottle] (TARO)
25 % = $31.19
75 % = $86.35 - Cormax 0.05 % SOLN [Bottle] (WATSON LABS)
50 % = $79.99
150 % = $239.96 - Olux 0.05 % FOAM [Can] (GLAXO SMITH KLINE)
100 % = $456
300 % = $1330.04 - Clobetasol Propionate 0.05 % OINT [Tube] (TARO)
60 % = $40.99
180 % = $114.96 - Temovate E 0.05 % CREA [Tube] (PHARMADERM)
15 % = $40.99
45 % = $112.97 - Clobex Spray 0.05 % LIQD [Bottle] (GALDERMA)
125 % = $503.99
375 % = $1470.02 - Clobetasol Propionate 0.05 % CREA [Tube] (TARO)
45 % = $29.99
135 % = $85.16 - Clobetasol Propionate 0.05 % CREA [Tube] (TARO)
60 % = $39.99
180 % = $111.96 - Temovate 0.05 % CREA [Tube] (PHARMADERM)
60 % = $262
180 % = $755.98 - Clobetasol Propionate 0.05 % GEL [Tube] (FOUGERA)
60 % = $42.99
180 % = $121.96 - Temovate 0.05 % OINT [Tube] (PHARMADERM)
15 % = $93.99
45 % = $240.97 - Clobetasol Propionate 0.05 % FOAM [Can] (PERRIGO PHARMACEUTICALS)
50 % = $119.99
150 % = $309.98 - Olux 0.05 % FOAM [Can] (GLAXO SMITH KLINE)
50 % = $239.06
150 % = $709.44 - Temovate E 0.05 % CREA [Tube] (PHARMADERM)
60 % = $213.98
180 % = $602.96 - Clobex Spray 0.05 % LIQD [Bottle] (GALDERMA)
59 % = $274.99
177 % = $800.98 - Temovate 0.05 % GEL [Tube] (PHARMADERM)
60 % = $205.99
120 % = $411.99 - Temovate 0.05 % CREA [Tube] (PHARMADERM)
30 % = $126.98
90 % = $359.95 - Clobex 0.05 % SHAM [Bottle] (GALDERMA)
118 % = $423.01
354 % = $1241.89 - Temovate 0.05 % OINT [Tube] (PHARMADERM)
30 % = $152.99
90 % = $434.99 - Clobetasol Propionate 0.05 % OINT [Tube] (TARO)
45 % = $38.99
135 % = $112.98 - Temovate 0.05 % SOLN [Bottle] (PHARMADERM)
50 % = $190.98
150 % = $555.96 - Clobex 0.05 % LOTN [Bottle] (GALDERMA)
59 % = $318.53
177 % = $931.86 - Clobex 0.05 % LOTN [Bottle] (GALDERMA)
118 % = $575.89
354 % = $1603.84
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.