Adult Dosing

Constipation

docusate sodium (generic)

• 50–400 mg/day divided daily-qid

Colace

• CAPS: 50-300 mg/day PO divided daily-bid PRN
• SOLN: 5-15 mL PO daily PRN
• SYRUP: 15-90 mL/day PO divided daily-bid PRN

DulcoEase Pink Stool Softener, Dulcolax Stool Softener

• 1-3 Caps PO divided daily-tid PRN

Fleet Sof-Lax

• 1-3 Caps PO divided daily-tid PRN

Phillips Stool Softner

• 1-3 Caps PO divided daily-tid PRN

Pediatric Dosing

Constipation

docusate sodium (generic)

• Child >12 yrs: 50–400 mg/day divided daily-qid
• Child 6-12 yrs: 40–150 mg/day divided daily-qid
• Child 3-6 yrs: 20–60 mg/day divided daily-qid
• Child <3 yrs: 10–40 mg/day divided daily-qid

Colace

• CAPS:
• 2-11 yrs: 50-150 mg/day PO divided daily-bid PRN
• >12 yrs: 50-300 mg/day PO divided daily-bid PRN

• SOLN:
• 2-11 yrs: 5-15 mL PO daily PRN
• >12 yrs: 5-15 mL PO daily PRN

• SYRUP:
• 2-11 yrs: 15-37.5 mL/day PO divided daily-bid PRN
• >12 yrs: 15-90 mL/day PO divided daily-bid PRN

DulcoEase Pink Stool Softener, Dulcolax Stool Softener

• 2-11 yrs: 1 Cap PO daily PRN
• >12 yrs: 1-3 Caps PO divided daily-tid PRN

Fleet Sof-Lax

• 2-11 yrs: 1 Cap PO daily PRN
• >12 yrs: 1-3 Caps PO divided daily-tid PRN

Pedia Lax Stool Softner

• 15-45 mL PO daily PRN; Max: 45 mL/24 hrs

Phillips Stool Softner

• 6-11 yrs: 1 Cap PO daily PRN
• >12 yrs: 1-3 Caps PO divided daily-tid PRN

• Constipation (softening stool)

• Hypersensitivity to any of the ingredients of the product
• Fecal impaction
• Mineral oil use
• Appendicitis
• Acute abdomen
• GI obstruction

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Do not administer therapy in patients suffering from stomach pain, nausea or vomiting
• Suspend therapy if there is a sudden change in bowel habits lasting more than 2 weeks
• Do not administer if patient is already taking mineral oil
• Discontinue if rectal bleeding or no bowel movement occurs

Pregnancy Category:C

Breastfeeding: Safety unknown. Minimally absorbed from the GI and therefore the drug is unlikely to be found in the maternal serum or breastmilk. Laxatives that are completely unabsorbed may be preferred. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 12 May 2011).

• GI: Diarrhea, abdominal cramps, throat irritation, bitter taste
• DERM: Rash
• METABOLIC: Electrolyte disorders

• Stool softener; promotes electrolyte and water secretion into the colon, promotes incorporation of water into stool, resulting in softer fecal mass
• Minimally absorbed from the small intestine after oral administration
• Metabolism: Unknown
• Half-life: Unknown

US Trade Name(s)

• Colace
• DulcoEase Pink Stool Softener
• Dulcolax Stool Softener
• Fleet Sof-Lax
• Pedia Lax Stool Softner
• Phillips Stool Softner

US Availability

docusate sodium (generic)

• CAPS: 50, 100, 250 mg
• SOLN: 4 mg/mL
• SOLN: 10 mg/mL

Colace

• CAPS: 50, 100 mg
• LIQ: 1% (30 mL)
• SYRUP: 473 mL

DulcoEase Pink Stool Softener, Dulcolax Stool Softener

• CAPS: 100 mg

Fleet Sof-Lax

• CAPS: 100 mg

Pedia Lax Stool Softner

• SOLN: 50 mg/15 mL

Phillips Stool Softner

• CAPS: 100 mg

Canadian Trade Name(s)

• Calax
• Colace
• Correctol Stool Softener
• Selax

Canadian Availability

docusate sodium (generic)

• CAPS: 100, 200, 250 mg
• SYRUP: 4 mg/mL
• SYRUP: 10 mg/mL
• SYRUP: 20 mg/mL
• SYRUP: 50 mg/mL

Calax

• CAPS: 240 mg

Colace

• CAPS: 100 mg
• SYRUP: 4 mg/mL

Correctol Stool Softener

• CAPS: 100 mg

Selax

• CAPS: 250 mg

UK Trade Name(s)

• Calax
• Colace
• Correctol Stool Softener

UK Availability

docusate sodium (generic)

• CAPS: 100, 240 mg
• SYRUP: 20 mg/5 mL
• SYRUP: 10 mg/mL
• DROPS: 10 mg/mL

Calax

• CAPS: 240 mg

Colace

• CAPS: 100 mg
• DROPS: 10 mg/mL
• SYRUP: 4 mg/mL

Correctol Stool Softener

• CAPS: 100 mg

Australian Trade Name(s)

• Coloxyl

Australian Availability

Coloxyl

• TABS: 50, 120 mg

Gastrointestinal

Laxatives

Stool Softeners

Pricing data from www.DrugStore.com in U.S.A.

• Docusate Sodium 250 MG CAPS [Bottle] (RUGBY)
  100 mg = $15.99
  200 mg = $22.98
• Docusate Sodium 100 MG CAPS [Bottle] (RUGBY)
  1000 mg = $27.99
  2000 mg = $45.97
• Colace 100 MG CAPS [Bottle] (PURDUE PRODUCTS LP)
  60 mg = $26.99
  120 mg = $43.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.

• DOCUSATE SODIUM 100 mg (McKesson Packaging Services Business Unit of McKesson Corporation)
• DOCUSATE SODIUM 100 mg (SPIRIT PHARMACEUTICALS,LLC)
• DOCUSATE SODIUM 50 mg (SPIRIT PHARMACEUTICALS,LLC)