Adult Dosing
Cryoprin-Associated Periodic Syndromes
- Loading Dose: Two 160 mg SC doses administered on the same day at 2 different sites. Total: 320 mg/day
- Maintenance dose: 160 mg SC qwk
Pediatric Dosing
Cryoprin-Associated Periodic Syndromes
Child (12-17 yrs)
- Loading Dose: 4.4 mg/kg SC divided administered as single or two injections on the same day at 2 different sites. [Max: 320 mg/day]
- Maintenance dose: 2.2 mg/kg SC qwk. [Max: 160 mg/day]
- Serious life threatening infections have been reported; discontinue therapy if such reactions occur
- Increased risk of malignancies with concomitant immunosuppressants
- Do not initiate treatment in active or chronic infection
- Latent TB should be treated prior to using
- Co-administration with TNF-blockers is contraindicated
- Do not administer live vaccines concurrently with rilonacept; give all recommended vaccines before initiating therapy with this drug
- Monitor patients for development of opportunistic infections
- Monitor lipid profile periodically during therapy
- Rare hypersensitivity reactions may occur; discontinue therapy in event of a hypersensitivity reaction
Cautions: Use Cautiously in
- Patients at risk of infections
- Lactation
- Pediatric population (safety not established for children <12 yrs)
Pregnancy Category:C
Breastfeeding: Safety unknown; manufacturer advises caution.
