Adult Dosing

Symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy

• 125 mg PO bid

Pediatric Dosing

• Safety and effectiveness have not been established in patients < 18 years of age

[Outline]

• Adult Dosing
• Pediatric Dosing

• Symptomatic relief of non-infectious diarrhea in adult patients with HIV/AIDS on anti-retroviral therapy

• Hypersensitivity to any of the ingredients of the product

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Therapy is not indicated for infectious diarrhea; before initiating, rule out infectious etiologies of diarrhea as there is a risk that patients with infectious etiologies will not receive the appropriate treatments, and their disease may worsen

Pregnancy Category:B

Breastfeeding: It is not known whether crofelemer is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

• CNS: Anxiety
• RESP: Upper respiratory tract infection, bronchitis, cough
• EENT: Nasopharyngitis
• GI: Flatulence, nausea, abdominal distension, hemorrhoids, giardiasis
• LAB TESTS: Increased bilirubin, increased alanine aminotransferase
• MUSC: Back pain, arthralgia, musculoskeletal pain
• GU: Urinary tract infection

• Inhibitor of cAMP stimulated cystic fibrosis transmembrane conductance regulator (CFTR) chloride (Cl) ion channel and the calcium-activated channels (CaCC); acts by blocking Cl secretion and accompanying high volume water loss in diarrhea, normalizing the flow of Cl and water in the GI tract
• Minimally absorbed following oral administration
• Metabolism: No metabolites identified
• Elimination: Not identified

US Trade Name(s)

• Fulyzaq

US Availability

Fulyzaq

• Delayed Release TABS: 125mg

Canadian Trade Name(s)

• N/A

Canadian Availability

• N/A

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

Gastrointestinal

Antidiarrheals

Catechins