Adult Dosing

Acute otitis media

• Instill in the ear(s), allowing the solution to run along the wall of the ear canal until it is filled, moisten a cotton pledget with the solution and insert into meatus
• Repeat q1-2 hrs, until pain and congestion are relieved

Removal of cerumen

• Instill in the ear(s) tid x 2-3 days to help remove cerumen from the wall of the ear canal
• Use PRN after cerumen removal for drying out the ear canal or relieving discomfort
• Following instillation, insert a cotton pledget moistened with the solution into the meatus before and after cerumen removal

Pediatric Dosing

Acute otitis media

• Instill in the ear(s), allowing the solution to run along the wall of the ear canal until it is filled, moisten a cotton pledget with the solution and insert into meatus
• Repeat q1-2 hrs, until pain and congestion are relieved

Removal of cerumen

• Instill in the ear(s) tid x 2-3 days to help remove cerumen from the wall of the ear canal
• Use PRN after cerumen removal for drying out the ear canal or relieving discomfort
• Following instillation, insert a cotton pledget moistened with the solution into the meatus before and after cerumen removal

[Outline]

• Adult Dosing
• Pediatric Dosing

• Treatment of acute otitis media which includes:
• Pain relief and reduction of inflammation in the congestive and serous stages
• Adjuvant therapy during systemic antibiotic administration for resolution of infection

• Removal of excessive or impacted cerumen

• Hypersensitivity to any of the ingredients of the product
• Spontaneous perforation of the tympanic membrane or discharge

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

See Supplemental Patient Information

• For use in ears only; not for ophthalmic use
• Keep medication out of reach of children
• Instruct patients to promptly discontinue therapy if sensitization or irritation occurs
• Advise patients to avoid touching the dropper tip to any surface including ears in order to avoid contamination

Caution: Use cautiously in

• Breastfeeding

Supplemental Patient Information

• Advise patients to avoid contaminating the dropper with material from the ear, fingers, or other source
• Advise patients to avoid rinsing the dropper after use
• Instruct patients to discard this product 6 months after dropper is first placed in the drug solution

Pregnancy Category:C

Breastfeeding: Antipyrine is not expected to harm the breastfed infant as it is unlikely to be systemically absorbed by the mother and reach breastmilk. Also, topical benzocaine is unlikely to affect the breastfed infant when used at sites other than breasts. This information is based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 24 June 2011). Manufacturer advises caution.

• EENT: Ear sensitization, ear irritation, ear pain, ear pruritus

Antipyrine

• Analgesic and antipyretic; inhibits both isoforms of cyclooxygenase, COX-1 and COX-2, enzymes involved in prostaglandin synthesis, thereby increasing pain threshold
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

Benzocaine

• Local anesthetic; stabilizes neuronal cell membranes by binding to sodium channels, thereby decreasing its permeability to sodium ions. Blocks initiation and conduction of nerve impulses
• Minimal systemic absorption
• Metabolism: Unknown
• Excretion: Unknown
• Half-life: Unknown

US Trade Name(s)

• A/B Otic

US Availability

antipyrine/benzocaine (generic)

• OTIC SOLN: 5.4%/1.4%

A/B Otic

• OTIC SOLN: 5.4%/1.4%

Canadian Trade Name(s)

• Auralgan

Canadian Availability

Auralgan

• OTIC SOLN: 5.4%/1.4%

UK Trade Name(s)

• N/A

UK Availability

• N/A

Australian Trade Name(s)

• N/A

Australian Availability

• N/A

[Outline]

ENT

Otic Agents

Miscellaneous

Pricing data from www.DrugStore.com in U.S.A.

• A/B Otic 1.4-5.4 % SOLN [Bottle] (QUALITEST)
  15 % = $12.99
  30 % = $15.98
• Antipyrine-Benzocaine 5.4-1.4 % SOLN [Bottle] (BAUSCH & LOMB)
  10 % = $46.06
  20 % = $53.12

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.