Adult Dosing

2nd/3rd degree burns

• Apply 1% cream qd-bid (1.5 mm thick) on cleansed debrided areas

Pediatric Dosing

• Safety and effectiveness in children have not been established

2nd/3rd degree burns (Not FDA approved)

• Apply 1% cream qd-bid; cover with light dressings

[Outline]

• Adult Dosing
• Pediatric Dosing

• As an adjunct for the prevention and treatment of wound sepsis in patients with second and third degree burns

• Hypersensitivity to any of the ingredients of the product
• Allergy to sulfa drugs
• Pregnancy
• Patients < 2 months

• N/A

Renal Dose Adjustment

• Renal impairment: Dose adjustments not defined

Hepatic Dose Adjustment

• Hepatic impairment: Dose adjustments not defined

• Therapy can cause adverse reaction associated with sulfonamides including blood dyscrasias (agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia), dermatologic and allergic reactions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and exfoliative dermatitis, gastrointestinal reactions, hepatitis and hepatocellular necrosis, CNS reactions, and toxic nephrosis. Continuation of therapy must be weighed against the potential hazards of the particular allergic reaction
• Monitor serum sulfa levels and renal function in patients with extensive burns
• Therapeutic drug levels are 8-12 mg/dL; toxic levels > 12 mg/dL
• Leukopenia (primarily decreased neutrophil count) has been reported
• Monitor renal function and perform urine analysis (check for sulfa crystals)

Cautions: Use cautiously in

• Hepatic impairment
• Renal impairment
• Lactation
• Pediatric population
• G6PD deficiency

Pregnancy Category:B

• Should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life
• Avoid use in third trimester of pregnancy due to risk of neonatal hemolysis and methemoglobinemia

Breastfeeding: Safety unknown; however sulfonamides are known to be excreted in breastmilk. Because of the potential for possible serious adverse reactions in nursing infants, manufacturer recommends discontinuation of breastfeeding, or postponing of treatment (taking into account the importance of the drug to the mother).

• HEMA: Leukopenia, neutropenia
• DERM: Skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes
• GI: Interstitial nephritis
• MISC: Pain

• Sulfonamide antibacterial; inhibits bacteria by acting on cell membrane and cell wall
• Minimal systemic availability after topical application; 10% systemic availability of sulfadiazine; 1% systemic availability for silver
• Renally excreted; mostly unchanged
• Half-life: Unknown

US Trade Name(s)

• Silvadene
• SSD
• SSD AF
• Thermazene

US Availability

silver sulfadiazine (generic)

• CRE: 1% (50, 85, 400 g )

Silvadene

• CRE: 1% (20, 85 g tubes)
• CRE: 1% (50, 400, 100 g jars)

SSD, SSD-AF

• CRE: 1%

Thermazene

• CRE: 1% (20, 50, 85 g tubes)
• CRE: 1% (400, 1000 g jars)

Canadian Trade Name(s)

• Dermazin
• Flamazine

Canadian Availability

Dermazin

• CRE: 1%

Flamazine

• CRE: 1% (20, 50 g tubes)
• CRE: 1% (500 g jars)

UK Trade Name(s)

• Flamazine

UK Availability

Flamazine

• CRE: 1% (20, 50 tubes)
• CRE: 1% (250, 500 g jars)

Australian Trade Name(s)

• Silvazine

Australian Availability

Silvazine (with chlorhexidine 0.2%)

• CRE: 1% (50, 100, 500 g)

[Outline]

Antimicrobials

Dermatologic Topical Agents

Antibiotics

Infectious Disease

Dermatologic Topical Agents

Antibiotics

Dermatologic

Dermatologic Topical Agents

Antibiotics

Pricing data from www.DrugStore.com in U.S.A.

• Thermazene 1 % CREA [Tube] (SHERWOOD MEDICAL)
  20 % = $13.99
  40 % = $19.98
• Silvadene 1 % CREA [Jar] (MONARCH PHARMACEUTICALS)
  400 % = $73.99
  1200 % = $198.96
• Silvadene 1 % CREA [Jar] (MONARCH PHARMACEUTICALS)
  50 % = $24.99
  100 % = $40.97
• SSD 1 % CREA [Jar] (PAR)
  50 % = $14.99
  150 % = $25.97
• SSD 1 % CREA [Jar] (DR.REDDY'S LABORATORIES)
  400 % = $32.99
  1200 % = $85.97
• Silver Sulfadiazine 1 % CREA [Jar] (WATSON LABS)
  25 % = $13.99
  50 % = $17.97
• Silver Sulfadiazine 1 % CREA [Jar] (WATSON LABS)
  85 % = $19.99
  170 % = $29.97
• Silvadene 1 % CREA [Tube] (MONARCH PHARMACEUTICALS)
  20 % = $27.99
  60 % = $52.97
• Silvadene 1 % CREA [Tube] (MONARCH PHARMACEUTICALS)
  85 % = $38.99
  255 % = $93.97
• Silver Sulfadiazine 1 % CREA [Jar] (WATSON LABS)
  400 % = $32.99
  1200 % = $95.97

Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.