Adult Dosing
Ear, nose, and throat; skin and skin structure; genitourinary tract
- Mild/moderate infections: 250 mg PO q8 hrs or 500 mg PO q12 hrs
- Severe infections: 500 mg PO q8 hrs or 875-1000 mg PO q12 hrs
Lower Respiratory Tract Infections (Mild/moderate or Severe infections)
- 875-1000 mg PO q12 hrs or 500 mg PO q8 hrs
Gonorrhea Acute (where penicillin resistant strains not present), uncomplicated urinary tract infection in male and female (use caution with this as not that clinically effective)
Streptococcal pharyngitis
- Moxatag formulation, 775 mg/day PO x 10 days
H. Pylori Eradication
- Triple Therapy: 1 g PO bid for 14 days with clarithromycin and lansoprazole
- Dual therapy: 1 g PO bid for 14 days with lansoprazole
Endocarditis Prophylaxis
- 2 g PO 1 hr prior to procedure
Pharyngitis (Acute) [Non-FDA Approved]
- 500 mg PO bid or 1000 mg PO qd x 10 days
Chlamydia in pregnant women [Non-FDA Approved]
COPD exacerbation[Non-FDA Approved]
Pediatric Dosing
Acute otitis media
Child
- <3 month: 20-30 mg/kg/day PO q12 hrs (Max: 30 mg/kg/day)
- >3 month: 35-50 mg/kg/day PO div q8-12 hrs or if PRSP suspected, 80-90 mg/kg/day PO div q8-12 hrs for 10 days (Max: 3 g/day)
Ear, nose, and throat; skin and skin structure; genitourinary tract
Child ( 40 kg)
- Mild/moderate infections: 250 mg PO q8 hrs or 500 mg PO q12 hrs
- Severe infections: 500 mg PO q8 hrs or 875-1000 mg PO q12 hrs
Child (3 months and younger)
- 30 mg/kg/day divided every 12 hr
Child (>3 months <40 kg)
- 45 mg/kg/day divided every 12 hr or 40 mg/kg/day every 8 hr
Lower Respiratory Tract Infections (Mild/moderate or Severe infections)
Child (3 months and younger)
- 30 mg/kg/day divided every 12 hr
Child ( 40 kg)
- 875-1000 mg PO q12 hrs or 500 mg PO q8 hrs
Child ( 3 mo and < 40 kg)
- 45 mg/kg/day PO q12 hrs or 40 mg/kg/day PO q8 hrs
Gonorrhea Acute (where penicillin resistant strains not present), uncomplicated urinary tract infection in male and female (use caution with this as not that clinically effective)
Prepubertal Child 2 yrs
- 50 mg/kg PO Amoxicillin combined with probenecid 25 mg/kg PO as a single dose
Streptococcal pharyngitis
Children>12 yrs
- Moxatag formulation, 775 mg PO qd x 10 days
Endocarditis Prophylaxis
- 50 mg/kg PO 1 hr prior to procedure
- Max: 2 g
Pharyngitis (Acute) [Non-FDA Approved]
- Children >12 yrs
- 500mg PO bid or 1000 mg PO qd x 10 days
- Children < 12 years
- 50 mg/kg/day PO div qd/bid (Max 1000 mg/day)
Pediatrics Pneumonia [Non-FDA Approved]
- 80-100 mg/kg/day PO given in divided bid-tid; Max: 3 g/day
[Outline]
Renal Dose Adjustment (Based on CrCl)
- <30 mL/min: Avoid administration of 875-mg tablet
- 10-30 mL/min: PO 250 mg or 500 mg q12 hrs
- <10 mL/min: PO 250 mg or 500 mg q24 hrs
- Hemodialysis: 500 mg or 250 mg q24 hrs
Hepatic Dose Adjustment
- Hepatic impairment: No dose adjustments defined
- Although indications exist for use of this agent for urinary tract infection and skin structure infection; other drugs should usually be chosen. In urinary tract infection, resistance is common. For skin structure infections, other drugs have better antistaphylococcal along with streptococcal coverage
- Amoxicillin causes serious and occasionally fatal hypersensitivity (anaphylactic) reactions have occurred in patients on penicillin therapy
- Cross sensitivity to cephalosporins possible
- If superinfections occur, amoxicillin should be discontinued and appropriate therapy instituted
- Monitor blood, renal, and hepatic function in long-term use
Cautions: Use cautiously in
- Renal impairment
- Hepatic impairment
- Infectious mononucleosis
Pregnancy Category:B
Breastfeeding: This drug is compatible and considered safe with breastfeeding based upon data from AAP Policy Guidelines (available at http://aappolicy.aappublications.org/cgi/content/full/pediatrics;108/3/776 ) and based upon LactMed database (available at http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT last accessed 29 August 2010).
Pricing data from www.DrugStore.com in U.S.A.
- Amoxicillin 500 MG TABS [Bottle] (TEVA PHARMACEUTICALS USA)
100 mg = $49.99
300 mg = $125.97 - Amoxicillin 250 MG/5ML SUSR [Bottle] (SANDOZ)
100 5ml = $13.99
200 5ml = $17.97 - Amoxicillin 875 MG TABS [Bottle] (AUROBINDO PHARMA)
30 mg = $26.99
90 mg = $70.97 - Amoxicillin 125 MG CHEW [Bottle] (TEVA PHARMACEUTICALS USA)
21 mg = $15.32
42 mg = $18.58 - Amoxicillin 250 MG CHEW [Bottle] (TEVA PHARMACEUTICALS USA)
30 mg = $17.51
90 mg = $29.53
Warning: This pricing information is subject to change at the sole discretion of DS Pharmacy. For the most current and up-to-date pricing information, please visit drugstore.com.